Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 8/20 | 0.70 |
| ▸ | WEE1 | P30291 | 7/20 | 0.70 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.67 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.67 |
| ▸ | CDK4 | P11802 | 5/20 | 0.58 |
| ▸ | CCND1 | P24385 | 5/20 | 0.58 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.58 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.58 |
| ▸ | CDK2 | P24941 | 1/20 | 0.58 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.58 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.58 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.58 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.58 |
| ▸ | GSK3A | P49840 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | PARP1 | P09874 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5829258 | 0.85 | PDGFRB (0.76) | CHEK1WEE1PDGFRBROCK2CDK4 | |
| SCHEMBL5829570 | 0.83 | PDGFRB (0.73) | CHEK1WEE1PDGFRBROCK2CDK4 | |
| SCHEMBL5829194 | 0.82 | CHEK1 (1.00) | CHEK1WEE1ROCK2CDK4GSK3A | |
| SCHEMBL5827984 | 0.82 | CHEK1 (0.72) | CHEK1WEE1PDGFRBROCK2CDK4 | |
| Gw296115X SCHEMBL31281911 | 0.81 | PDGFRB (1.00) | CHEK1WEE1PDGFRBROCK2CDK4 | |
| Gw296115X SCHEMBL8120713 | 0.81 | PDGFRB (1.00) | CHEK1WEE1PDGFRBROCK2CDK4 | |
| SCHEMBL8128623 | 0.81 | ROCK2 (1.00) | CHEK1WEE1PDGFRBROCK2CDK4 | |
| SCHEMBL5828138 | 0.80 | CHEK1 (0.73) | CHEK1WEE1PDGFRBROCK2CDK4 | |
| SCHEMBL5827986 | 0.79 | WEE1 (0.77) | CHEK1WEE1PDGFRBROCK2CDK4 | |
| SCHEMBL5829250 | 0.78 | PDGFRB (0.68) | CHEK1WEE1PDGFRBROCK2CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7094798-B1 | Inhibitors of checkpoint kinases (Wee1 and Chk1) | PFIZER INC (US) | 2006-08-22 | — | — | US | disclosed |