Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.76 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.76 |
| ▸ | CHEK1 | O14757 | 9/20 | 0.68 |
| ▸ | WEE1 | P30291 | 8/20 | 0.68 |
| ▸ | CDK4 | P11802 | 6/20 | 0.65 |
| ▸ | CCND1 | P24385 | 6/20 | 0.65 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.65 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.65 |
| ▸ | CDK2 | P24941 | 2/20 | 0.65 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.65 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.65 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.65 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.65 |
| ▸ | GSK3A | P49840 | 1/20 | 0.57 |
| ▸ | GSK3B | P49841 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | PRKACA | P17612 | 1/20 | 0.50 |
| ▸ | PRKACG | P22612 | 1/20 | 0.50 |
| ▸ | PRKACB | P22694 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5829570 | 0.93 | PDGFRB (0.73) | PDGFRBROCK2CHEK1WEE1CDK4 | |
| SCHEMBL5827984 | 0.92 | CHEK1 (0.72) | PDGFRBROCK2CHEK1WEE1CDK4 | |
| SCHEMBL5828138 | 0.90 | CHEK1 (0.73) | PDGFRBROCK2CHEK1WEE1CDK4 | |
| Gw296115X SCHEMBL31281911 | 0.87 | PDGFRB (1.00) | PDGFRBROCK2CHEK1WEE1CDK4 | |
| Gw296115X SCHEMBL8120713 | 0.87 | PDGFRB (1.00) | PDGFRBROCK2CHEK1WEE1CDK4 | |
| SCHEMBL8128623 | 0.86 | ROCK2 (1.00) | PDGFRBROCK2CHEK1WEE1CDK4 | |
| SCHEMBL5828449 | 0.85 | CHEK1 (0.70) | PDGFRBROCK2CHEK1WEE1CDK4 | |
| SCHEMBL5829135 | 0.81 | CHEK1 (1.00) | ROCK2CHEK1WEE1CDK4GSK3A | |
| SCHEMBL5827986 | 0.79 | WEE1 (0.77) | PDGFRBROCK2CHEK1WEE1CDK4 | |
| SCHEMBL4889527 | 0.78 | CDK4 (0.73) | PDGFRBROCK2CDK4CCND1CCNE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7094798-B1 | Inhibitors of checkpoint kinases (Wee1 and Chk1) | PFIZER INC (US) | 2006-08-22 | — | — | US | disclosed |