SCHEMBL5828510

SCHEMBL5828510

CCN(O)c1nc(NCc2ccccc2)c2ncn(C)c2n1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK1 P06493 5/20 0.65
CDK2 P24941 4/20 0.62
CCNE2 O96020 3/20 0.62
CCNE1 P24864 3/20 0.62
CCNA2 P20248 2/20 0.62
CCNA1 P78396 2/20 0.62
CDK5 Q00535 2/20 0.62
KDM4E B2RXH2 2/20 0.62
MAPT P10636 2/20 0.62
TDP1 Q9NUW8 2/20 0.62
CCNB2 O95067 1/20 0.62
ALDH1A1 P00352 1/20 0.62
CYP1A2 P05177 1/20 0.62
CYP3A4 P08684 1/20 0.62
GAA P10253 1/20 0.62
CYP2D6 P10635 1/20 0.62
CCNB1 P14635 1/20 0.62
ALOX15 P16050 1/20 0.62
NFKB1 P19838 1/20 0.62
MAPK3 P27361 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5827485 0.79 CDK2 (0.61) CDK1CDK2CCNE2CCNE1CCNA2
SCHEMBL8010398 0.79 CDK1 (1.00) CDK1CDK2CCNE2CCNE1CCNA2
SCHEMBL7999866 0.79 CDK1 (1.00) CDK1CDK2CCNE2CCNE1CCNA2
SCHEMBL17442999 0.79 CDK1 (0.73) CDK1CDK2CCNE2CCNE1CCNA2
SCHEMBL13252976 0.78 CDK1 (0.81) CDK1CDK2CCNE2CCNE1CCNA2
Olomoucine SCHEMBL135056 0.77 CDK1 (1.00) CDK1CDK2CCNE2CCNE1CCNA2
SCHEMBL5827486 0.76 CDK2 (0.58) CDK1CDK2CCNE2CCNE1CCNA2
SCHEMBL5828515 0.76 CDK2 (0.74) CDK1CDK2CCNE2CCNE1CCNA2
SCHEMBL3965242 0.75 CDK1 (0.66) CDK1CDK2CCNE2CCNE1CCNA2
SCHEMBL14182620 0.75 CDK1 (0.87) CDK1CDK2CCNE2CCNE1CCNA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10866241-B2 Method for the prognosis and treatment of cancer metastasis INSTITUCIO CATALANA DE RECERCA I ESTUDIS AVANCATS (ES) 2020-12-15 US claimed
EP-3825692-B1 METHOD FOR THE PROGNOSIS AND TREATMENT OF CANCER METASTASIS FUNDACIO INST DE RECERCA BIOMEDICA IRB BARCELONA (ES) 2024-09-04 EP disclosed
EP-3553186-B1 METHOD FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF PROSTATE CANCER METASTASIS INBIOMOTION SL (ES) 2021-11-17 EP disclosed
EP-3825692-A1 METHOD FOR THE PROGNOSIS AND TREATMENT OF CANCER METASTASIS Fundació Institut de Recerca Biomèdica (IRB Barcelona) (ES) 2021-05-26 EP disclosed
EP-3272880-B1 METHOD FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF METASTATIC CANCER FUNDACIO INST DE RECERCA BIOMEDICA IRB BARCELONA (ES) 2020-11-25 EP disclosed
EP-2971113-B1 METHOD FOR THE PROGNOSIS AND TREATMENT OF CANCER METASTASIS FUNDACIO INST DE RECERCA BIOMEDICA IRB BARCELONA (ES) 2020-08-12 EP disclosed
EP-3553186-A1 METHOD FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF PROSTATE CANCER METASTASIS Inbiomotion S.L. (ES) 2019-10-16 EP disclosed
EP-2906718-B1 METHOD FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF PROSTATE CANCER METASTASIS USING C-MAF INBIOMOTION SL (ES) 2019-05-15 EP disclosed
EP-3467124-A1 METHOD FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF LUNG CANCER METASTASIS Fundació Institut de Recerca Biomèdica IRB (Barcelona) (ES) 2019-04-10 EP disclosed
EP-2859120-B1 METHOD FOR THE DIAGNOSIS AND PROGNOSIS OF LUNG CANCER METASTASIS FUNDACIO INST DE RECERCA BIOMEDICA IRB BARCELONA (ES) 2018-11-14 EP disclosed
US-6794390-B2 TREATING CELL PROLIFERATIVE DISORDERS SUCH AS RHEUMATOID ARTHRITIS, LUPUS, TYPE I DIABETES, MULTIPLE SCLEROSIS, CANCER, RESTENOSIS, HOST GRAFT DISEASE, GOUT, AND POLYCYSTIC KIDNEY DISEASE. CV THERAPEUTICS, INC. 2004-09-21 US disclosed
US-6790958-B2 ANTIPROLIFERATIVE AGENTS; FUNGICIDES LUM ROBERT T (US) 2004-09-14 US disclosed
US-20020032327-A1 Purine inhibitors of cyclin dependent kinase 2 & IkappaBalpha CV THERAPEUTICS, INC. 2002-03-14 US disclosed
EP-1150982-A1 PURINE INHIBITORS OF CYCLIN DEPENDENT KINASE 2 AND I$g(k)-A$g(a) CV THERAPEUTICS, INC. (US) 2001-11-07 EP disclosed
WO-2000044750-A1 PURINE INHIBITORS OF CYCLIN DEPENDENT KINASE 2 AND Iλ-A$g(a) CV THERAPEUTICS, INC. (US) 2000-08-03 WO disclosed
EP-1021186-A1 PURINE INHIBITORS OF CYCLIN DEPENDENT KINASE 2 AND IkappaB-alpha CV THERAPEUTICS, INC. (US) 2000-07-26 EP disclosed
EP-1021186-A4 PURINE INHIBITORS OF CYCLIN DEPENDENT KINASE 2 AND IkappaB-alpha CV THERAPEUTICS INC (US) 2000-07-26 EP disclosed
US-5866702-A Purine inhibitors of cyclin dependent kinase 2 CV THERAPEUTICS, INCORPORATION (US) 1999-02-02 US disclosed
WO-1998005335-A9 PURINE INHIBITORS OF CYCLIN DEPENDENT KINASE 2 AND IλB-$g(a) 1998-05-28 WO disclosed
WO-1998005335-A1 PURINE INHIBITORS OF CYCLIN DEPENDENT KINASE 2 AND IλB-$g(a) CV THERAPEUTICS, INC. (US) 1998-02-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10866241-B2 Method for the prognosis and treatment of cancer metastasis MAFG, BRCA1, BCOR CDK1 2928/4885CDK2 4303/4885CCNE2 2197/4885
US-20020032327-A1 Purine inhibitors of cyclin dependent kinase 2 & IkappaBalpha CDKN1A, CCNK, CDK1 CDK1 3/4885CDK2 4/4885CCNE2 132/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.