Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.33 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.33 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.33 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.33 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.33 |
| ▸ | KDM4A | O75164 | 5/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 5/20 | 0.32 |
| ▸ | KDM5A | P29375 | 1/20 | 0.32 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.32 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.32 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5621455 | 0.87 | ALDH1A1 (0.39) | ALDH1A1TSHRDNM1CYP1A2CYP2D6 | |
| SCHEMBL6983226 | 0.82 | CA12 (0.42) | ALDH1A1TSHRTDP1CYP2C9CYP2C19 | |
| SCHEMBL1307414 | 0.78 | ALDH1A1 (0.45) | ALDH1A1TSHRDNM1TDP1CYP1A2 | |
| SCHEMBL1290871 | 0.74 | ALDH1A1 (0.75) | ALDH1A1TSHRDNM1TDP1CYP2C9 | |
| SCHEMBL212626 | 0.74 | — | — | |
| SCHEMBL26771 | 0.74 | CA12 (0.37) | ALDH1A1TSHRDNM1TDP1KDM4C | |
| SCHEMBL97180 | 0.72 | DNM1 (0.43) | ALDH1A1TSHRDNM1KDM4CKDM5A | |
| SCHEMBL10790523 | 0.71 | ALDH1A1 (0.83) | ALDH1A1TSHRDNM1TDP1CYP2C9 | |
| Bromide SCHEMBL30558707 | 0.71 | ALDH1A1 (0.69) | ALDH1A1TSHRDNM1TDP1CYP2C9 | |
| SCHEMBL26135085 | 0.71 | ALDH1A1 (0.69) | ALDH1A1TSHRDNM1TDP1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7001904-B1 | Guanidine derivatives quinazoline and quinoline for use in the treatment of autoimmune diseases | ASTRAZENECA AB (SE) | 2006-02-21 | — | — | US | disclosed |
| EP-1296973-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | AstraZeneca AB (SE) | 2003-04-02 | — | — | EP | disclosed |
| WO-2002000644-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2002-01-03 | — | — | WO | disclosed |