Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.53 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 5/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20853005 | 0.86 | CA2 (0.50) | AXLPDGFRBPDGFRAKDM4EMEN1 | |
| SCHEMBL11160132 | 0.84 | AXL (0.61) | AXLPDGFRBPDGFRALOXL2KDM4E | |
| SCHEMBL92643 | 0.83 | AXL (0.59) | AXLPDGFRBPDGFRALOXL2KDM4E | |
| SCHEMBL29953506 | 0.83 | AXL (0.59) | AXLPDGFRBPDGFRALOXL2KDM4E | |
| SCHEMBL8346141 | 0.79 | AXL (0.54) | AXLPDGFRBPDGFRALOXL2KDM4E | |
| SCHEMBL8346137 | 0.79 | AXL (0.54) | AXLPDGFRBPDGFRALOXL2KDM4E | |
| SCHEMBL5829134 | 0.79 | AXL (0.50) | AXLPDGFRBPDGFRALOXL2KDM4E | |
| SCHEMBL5829136 | 0.79 | AXL (0.50) | AXLPDGFRBPDGFRALOXL2KDM4E | |
| SCHEMBL10771747 | 0.78 | AXL (0.67) | AXLPDGFRBPDGFRALOXL2KDM4E | |
| SCHEMBL4397800 | 0.78 | KDM4E (0.57) | AXLPDGFRBPDGFRALOXL2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7094798-B1 | Inhibitors of checkpoint kinases (Wee1 and Chk1) | PFIZER INC (US) | 2006-08-22 | — | — | US | disclosed |
| EP-1501831-A1 | INHIBITORS OF CHECKPOINT KINASES (WEE1 AND CHK1) | WARNER-LAMBERT COMPANY LLC (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003091255-A1 | INHIBITORS OF CHECKPOINT KINASES (WEE1 AND CHK1) | WARNER-LAMBERT COMPANY LLC (US) | 2003-11-06 | — | — | WO | disclosed |