Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 2/20 | 0.31 |
| ▸ | JAK3 | P52333 | 2/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24597201 | 0.83 | ALDH1A1 (0.42) | HSD11B1USP2ALDH1A1CYP3A4HPGD | |
| SCHEMBL23581731 | 0.83 | HSD11B1 (0.36) | HSD11B1NAMPTUSP2ALDH1A1CYP3A4 | |
| SCHEMBL23341530 | 0.74 | HSD11B1 (0.32) | HSD11B1 | |
| SCHEMBL17970231 | 0.73 | ALDH1A1 (0.44) | HSD11B1USP2ALDH1A1CYP3A4HPGD | |
| SCHEMBL23581752 | 0.72 | HSD11B1 (0.34) | HSD11B1NAMPT | |
| SCHEMBL3410101 | 0.71 | ALOX5AP (0.35) | NAMPT | |
| SCHEMBL17393808 | 0.70 | HSD11B1 (0.53) | HSD11B1NAMPTALDH1A1 | |
| SCHEMBL24597153 | 0.67 | ALDH1A1 (0.32) | USP2ALDH1A1CYP3A4HPGDHSD17B10 | |
| SCHEMBL1487254 | 0.67 | CA1 (0.36) | — | |
| SCHEMBL5297767 | 0.67 | CCR1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7101895-B2 | Cyclohexyl sulphone derivatives as gamma-secretase inhibitors | MERCK SHARP & DOHME LIMITED (GB) | 2006-09-05 | — | — | US | disclosed |
| US-20040122050-A1 | Cyclohexyl sulphone derivatives as gamma-secretase inhibitors | MERCK SHARP & DOHME LTD. (GB) | 2004-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040122050-A1 | Cyclohexyl sulphone derivatives as gamma-secretase inhibitors | BACE1, BACE2, APP | HSD11B1 147/4885NAMPT 2124/4885USP2 1562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.