Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 2/20 | 0.62 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.62 |
| ▸ | CTSV | O60911 | 2/20 | 0.50 |
| ▸ | CTSL | P07711 | 2/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5829207 | 1.00 | SRD5A1 (0.62) | SRD5A1SRD5A2CTSVCTSLPDGFRB | |
| SCHEMBL5829209 | 1.00 | SRD5A1 (0.62) | SRD5A1SRD5A2CTSVCTSLPDGFRB | |
| SCHEMBL5828319 | 0.86 | SRD5A1 (0.67) | SRD5A1SRD5A2CTSVCTSLPDGFRB | |
| SCHEMBL27631774 | 0.77 | CYP1A1 (0.53) | PDGFRBPDGFRACYP1A1CYP1A2CYP1B1 | |
| SCHEMBL3243291 | 0.77 | SRD5A2 (1.00) | SRD5A1SRD5A2CTSVCTSLPDGFRB | |
| SCHEMBL7169748 | 0.77 | SRD5A2 (1.00) | SRD5A1SRD5A2CTSVCTSLPDGFRB | |
| SCHEMBL30997265 | 0.76 | SRD5A1 (0.66) | SRD5A1SRD5A2CTSVCTSLPDGFRB | |
| SCHEMBL28820805 | 0.76 | SRD5A1 (0.66) | SRD5A1SRD5A2CTSVCTSLPDGFRB | |
| SCHEMBL5829229 | 0.75 | SRD5A2 (0.82) | SRD5A1SRD5A2CTSVCTSLPDGFRB | |
| SCHEMBL7159304 | 0.75 | SRD5A2 (0.82) | SRD5A1SRD5A2CTSVCTSLPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7094798-B1 | Inhibitors of checkpoint kinases (Wee1 and Chk1) | PFIZER INC (US) | 2006-08-22 | — | — | US | disclosed |
| EP-1501831-A1 | INHIBITORS OF CHECKPOINT KINASES (WEE1 AND CHK1) | WARNER-LAMBERT COMPANY LLC (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003091255-A1 | INHIBITORS OF CHECKPOINT KINASES (WEE1 AND CHK1) | WARNER-LAMBERT COMPANY LLC (US) | 2003-11-06 | — | — | WO | disclosed |