Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 15/20 | 1.00 |
| ▸ | CHEK1 | O14757 | 12/20 | 0.67 |
| ▸ | PRKCA | P17252 | 3/20 | 0.67 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.67 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.67 |
| ▸ | PRKCG | P05129 | 1/20 | 0.67 |
| ▸ | PRKCB | P05771 | 1/20 | 0.67 |
| ▸ | CDK4 | P11802 | 1/20 | 0.67 |
| ▸ | PRKCH | P24723 | 1/20 | 0.67 |
| ▸ | PRKCI | P41743 | 1/20 | 0.67 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.67 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.67 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.62 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9834703 | 0.87 | MAP3K11 (0.81) | WEE1CHEK1PRKCAPRKCQPRKCD | |
| SCHEMBL29414147 | 0.81 | WEE1 (1.00) | WEE1CHEK1PRKCAPRKCQPRKCD | |
| SCHEMBL6516584 | 0.81 | WEE1 (1.00) | WEE1CHEK1PRKCAPRKCQPRKCD | |
| SCHEMBL30250020 | 0.81 | WEE1 (1.00) | WEE1CHEK1PRKCAPRKCQPRKCD | |
| Water SCHEMBL29521708 | 0.80 | WEE1 (0.97) | WEE1CHEK1PRKCAPRKCQPRKCD | |
| SCHEMBL9259880 | 0.76 | ROCK2 (1.00) | WEE1CHEK1PRKCAPRKCQPRKCD | |
| SCHEMBL9833379 | 0.76 | WEE1 (0.61) | WEE1CHEK1PRKCAPRKCQPRKCD | |
| SCHEMBL5828952 | 0.76 | WEE1 (0.83) | WEE1CHEK1PRKCAPRKCQPRKCD | |
| SCHEMBL5828696 | 0.75 | WEE1 (1.00) | WEE1CHEK1PRKCAPRKCQPRKCD | |
| SCHEMBL5829227 | 0.74 | WEE1 (1.00) | WEE1CHEK1PRKCAPRKCQPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7094798-B1 | Inhibitors of checkpoint kinases (Wee1 and Chk1) | PFIZER INC (US) | 2006-08-22 | — | — | US | disclosed |