Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 2/20 | 0.61 |
| ▸ | MAP3K11 | Q16584 | 7/20 | 0.61 |
| ▸ | MAP3K9 | P80192 | 6/20 | 0.61 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.58 |
| ▸ | PRKCA | P17252 | 5/20 | 0.55 |
| ▸ | PRKCQ | Q04759 | 4/20 | 0.55 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.55 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.55 |
| ▸ | PRKCG | P05129 | 3/20 | 0.55 |
| ▸ | PRKCB | P05771 | 3/20 | 0.55 |
| ▸ | PRKCH | P24723 | 3/20 | 0.55 |
| ▸ | PRKCI | P41743 | 3/20 | 0.55 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.55 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.55 |
| ▸ | PRKD1 | Q15139 | 3/20 | 0.55 |
| ▸ | GLI1 | P08151 | 2/20 | 0.55 |
| ▸ | GLI2 | P10070 | 2/20 | 0.55 |
| ▸ | CDK4 | P11802 | 1/20 | 0.55 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.55 |
| ▸ | PRKACA | P17612 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9834703 | 0.84 | MAP3K11 (0.81) | WEE1MAP3K11MAP3K9ROCK2PRKCA | |
| SCHEMBL9834200 | 0.82 | MAP3K9 (0.58) | WEE1MAP3K11MAP3K9ROCK2PRKCA | |
| SCHEMBL5829454 | 0.76 | WEE1 (1.00) | WEE1MAP3K11MAP3K9ROCK2PRKCA | |
| Staurosporinone SCHEMBL29389399 | 0.72 | MAP3K11 (1.00) | MAP3K11MAP3K9ROCK2PRKCAPRKCQ | |
| SCHEMBL16131549 | 0.72 | MAP3K11 (0.56) | WEE1MAP3K11MAP3K9ROCK2PRKCA | |
| Staurosporinone SCHEMBL5440281 | 0.72 | MAP3K11 (1.00) | MAP3K11MAP3K9ROCK2PRKCAPRKCQ | |
| Staurosporinone SCHEMBL29374983 | 0.72 | MAP3K11 (1.00) | MAP3K11MAP3K9ROCK2PRKCAPRKCQ | |
| Carbazole SCHEMBL27571745 | 0.70 | ALDH1A1 (0.64) | WEE1IKBKBPIM1PARP1CHEK1 | |
| SCHEMBL5828678 | 0.69 | WEE1 (1.00) | WEE1PRKCAPRKCQPRKCDPRKD3 | |
| SCHEMBL30565440 | 0.69 | IMPDH2 (0.72) | WEE1CDK4CCND1PARP1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0362695-B1 | PYRROLOCARBAZOLE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1991-04-03 | — | — | EP | disclosed |
| EP-0362695-A1 | Pyrrolocarbazole derivatives, processes for their preparation and their use as medicaments | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1990-04-11 | — | — | EP | disclosed |
| US-4912107-A | Pyrrolocarbazole derivatives, compositions containing them, and methods for using them | GOEDECKE AKTIENGESELLSCHAFT (DE) | 1990-03-27 | — | — | US | disclosed |