Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 13/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 12/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 11/20 | 0.46 |
| ▸ | PARP1 | P09874 | 3/20 | 0.45 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5879313 | 0.90 | OPRD1 (0.64) | OPRD1OPRM1OPRK1 | |
| SCHEMBL5829609 | 0.89 | OPRD1 (0.46) | OPRD1OPRM1OPRK1PARP1PARP2 | |
| SCHEMBL5830263 | 0.87 | OPRD1 (0.68) | OPRD1OPRM1OPRK1 | |
| SCHEMBL5830028 | 0.86 | OPRD1 (0.55) | OPRD1OPRM1OPRK1PARP2 | |
| SCHEMBL5829898 | 0.85 | OPRD1 (0.51) | OPRD1OPRM1OPRK1PARP1PARP2 | |
| SCHEMBL6746450 | 0.85 | OPRM1 (0.37) | OPRD1OPRM1OPRK1PARP1PARP2 | |
| SCHEMBL5829862 | 0.85 | OPRD1 (0.58) | OPRD1OPRM1OPRK1PARP1 | |
| SCHEMBL5829735 | 0.84 | OPRD1 (0.51) | OPRD1OPRM1OPRK1PARP1PARP2 | |
| SCHEMBL5632123 | 0.83 | OPRD1 (0.60) | OPRD1OPRM1OPRK1 | |
| SCHEMBL5829870 | 0.83 | OPRM1 (0.53) | OPRD1OPRM1OPRK1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1395557-A1 | 4-(phenyl-(piperidin-4-yl)-amino)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders | AstraZeneca AB (SE) | 2004-03-10 | — | — | EP | claimed |
| WO-2002094785-A1 | 4-(phenyl-(piperidin-4-yl)-amino)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders | ASTRAZENECA AB (SE) | 2002-11-28 | — | — | WO | claimed |
| US-7008952-B2 | 4-(phenyl-(piperidin-4yl)-amino)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders | ASTRAZENECA AB (SE) | 2006-03-07 | — | — | US | disclosed |