Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPD1 | P10809 | 5/20 | 0.48 |
| ▸ | PTPN2 | P17706 | 5/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.48 |
| ▸ | PTPN5 | P54829 | 5/20 | 0.48 |
| ▸ | HSPE1 | P61604 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | TP53 | P04637 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.44 |
| ▸ | STAT1 | P42224 | 2/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5831901 | 0.84 | HSPD1 (0.46) | HSPD1PTPN2PTPN1PTPN5HSPE1 | |
| SCHEMBL11696502 | 0.83 | NPC1 (0.50) | PTPN2PTPN1PTPN5NPC1KDM4E | |
| SCHEMBL5832686 | 0.81 | NPC1 (0.51) | NPC1KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL5832742 | 0.80 | S1PR1 (0.56) | HSPD1PTPN2PTPN1PTPN5HSPE1 | |
| SCHEMBL5832530 | 0.80 | PTGS2 (0.52) | NPC1KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL5832760 | 0.77 | NPC1 (0.71) | PTPN2PTPN1PTPN5NPC1KDM4E | |
| SCHEMBL11376453 | 0.77 | NPC1 (0.47) | HSPD1PTPN2PTPN1PTPN5HSPE1 | |
| SCHEMBL5832553 | 0.76 | NPC1 (0.55) | PTPN2PTPN1PTPN5NPC1KDM4E | |
| SCHEMBL2947283 | 0.74 | S1PR1 (0.68) | S1PR1 | |
| SCHEMBL5832705 | 0.73 | NPC1 (0.58) | PTPN2PTPN1PTPN5NPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7087601-B2 | Metabotropic glutamate receptor-5 modulators | MERCK & CO., INC. (US) | 2006-08-08 | — | — | US | disclosed |
| EP-1453815-A4 | METABOTROPIC GLUTAMATE RECEPTOR-5 MODULATORS | MERCK & CO INC (US) | 2005-04-06 | — | — | EP | disclosed |
| US-20050065340-A1 | Metabotropic glutamate receptor-5 modulators | MERCK SHARP & DOHME CORP. | 2005-03-24 | — | — | US | disclosed |
| EP-1453815-A1 | METABOTROPIC GLUTAMATE RECEPTOR-5 MODULATORS | Merck & Co., Inc. (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2004030637-A2 | TREATMENT OF OBESITY AND OTHER DISORDERS ASSOCIATED WITH EXCESSIVE FOOD INTAKE | MERCK & CO., INC. (US) | 2004-04-15 | — | — | WO | disclosed |
| WO-2003048137-A1 | METABOTROPIC GLUTAMATE RECEPTOR-5 MODULATORS | MERCK & CO., INC. (US) | 2003-06-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050065340-A1 | Metabotropic glutamate receptor-5 modulators | GRM5, GRIK5, GRM1 | HSPD1 1592/4885PTPN2 2238/4885PTPN1 2167/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.