Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Pyridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 5/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridine SCHEMBL27274943 | 0.94 | TSHR (0.64) | TSHRNAPRTTDP1LOXL2CHRNA7 | |
| Pyridine SCHEMBL2512471 | 0.94 | TSHR (0.64) | TSHRNAPRTTDP1LOXL2CHRNA7 | |
| Pyridine SCHEMBL5833723 | 0.83 | TSHR (0.82) | TSHRNAPRTTDP1CYP2A6 | |
| Pyridine SCHEMBL1310722 | 0.79 | TSHR (0.90) | TSHRNAPRTTDP1CYP2A6 | |
| Pyridine SCHEMBL346198 | 0.79 | — | — | |
| Benzene SCHEMBL23044989 | 0.79 | TSHR (0.90) | TSHRNAPRTTDP1CYP2A6 | |
| Pyridine SCHEMBL4530165 | 0.79 | — | — | |
| Pyridine SCHEMBL4610071 | 0.79 | TSHR (0.90) | TSHRNAPRTTDP1CYP2A6 | |
| Pyridine SCHEMBL1457193 | 0.79 | — | — | |
| Pyridine SCHEMBL1626309 | 0.79 | TSHR (0.90) | TSHRNAPRTTDP1CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7005532-B2 | Process of producing alkoxysilanes | TOAGOSEI CO., LTD. (JP) | 2006-02-28 | — | — | US | disclosed |
| US-20050020845-A1 | Process of producing alkoxysilanes | TOAGOSEI CO., LTD. (JP) | 2005-01-27 | — | — | US | disclosed |
| EP-1428828-A1 | PROCESS FOR PREPARATION OF ALKOXYSILANES | TOAGOSEI CO., LTD. (JP) | 2004-06-16 | — | — | EP | disclosed |