Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 9/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.35 |
| ▸ | CCR3 | P51677 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6600742 | 0.88 | OPRD1 (0.49) | OPRD1OPRM1OPRK1CYP3A4CYP2C9 | |
| SCHEMBL6600741 | 0.85 | OPRD1 (0.44) | OPRD1OPRM1OPRK1CYP3A4CYP2C9 | |
| SCHEMBL5833583 | 0.83 | CYP3A4 (0.39) | OPRD1OPRM1CYP3A4CYP2C9CYP1A2 | |
| SCHEMBL5630550 | 0.83 | OPRD1 (0.57) | OPRD1OPRM1OPRK1 | |
| SCHEMBL5879301 | 0.80 | OPRD1 (0.54) | OPRD1OPRM1OPRK1 | |
| SCHEMBL5833579 | 0.79 | CSNK1D (0.41) | CYP3A4CYP2C9CYP1A2CYP2C19TSHR | |
| SCHEMBL5879377 | 0.79 | OPRD1 (0.62) | OPRD1OPRM1OPRK1 | |
| SCHEMBL5879337 | 0.76 | OPRD1 (0.62) | OPRD1OPRM1OPRK1 | |
| SCHEMBL5879375 | 0.75 | OPRD1 (0.55) | OPRD1OPRM1OPRK1 | |
| SCHEMBL5879329 | 0.74 | OPRD1 (0.81) | OPRD1OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7008952-B2 | 4-(phenyl-(piperidin-4yl)-amino)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders | ASTRAZENECA AB (SE) | 2006-03-07 | — | — | US | claimed |