Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 14/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 11/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 11/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5879375 | 0.91 | OPRD1 (0.55) | OPRD1OPRM1OPRK1 | |
| SCHEMBL6600742 | 0.89 | OPRD1 (0.49) | OPRD1OPRM1OPRK1CYP1A2CYP3A4 | |
| SCHEMBL5829897 | 0.87 | OPRD1 (0.46) | OPRD1OPRM1OPRK1CHRM4 | |
| SCHEMBL5829869 | 0.86 | OPRM1 (0.47) | OPRD1OPRM1OPRK1 | |
| SCHEMBL5829860 | 0.86 | OPRD1 (0.52) | OPRD1OPRM1OPRK1CYP3A4 | |
| SCHEMBL6751098 | 0.85 | OPRD1 (0.49) | OPRD1OPRM1OPRK1 | |
| SCHEMBL5830262 | 0.85 | OPRD1 (0.61) | OPRD1OPRM1OPRK1CHRM4 | |
| SCHEMBL5833576 | 0.85 | OPRD1 (0.46) | OPRD1OPRM1OPRK1CYP1A2CYP3A4 | |
| SCHEMBL5630550 | 0.84 | OPRD1 (0.57) | OPRD1OPRM1OPRK1 | |
| SCHEMBL5830256 | 0.84 | OPRD1 (0.50) | OPRD1OPRM1OPRK1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1395557-A1 | 4-(phenyl-(piperidin-4-yl)-amino)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders | AstraZeneca AB (SE) | 2004-03-10 | — | — | EP | claimed |
| WO-2002094785-A1 | 4-(phenyl-(piperidin-4-yl)-amino)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders | ASTRAZENECA AB (SE) | 2002-11-28 | — | — | WO | claimed |