Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COMT | P21964 | 1/20 | 0.65 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.50 |
| ▸ | TNKS2 | Q9H2K2 | 10/20 | 0.48 |
| ▸ | TNKS | O95271 | 9/20 | 0.48 |
| ▸ | WNT3A | P56704 | 6/20 | 0.48 |
| ▸ | PARP2 | Q9UGN5 | 5/20 | 0.47 |
| ▸ | PARP1 | P09874 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.44 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.42 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.42 |
| ▸ | AXIN2 | Q9Y2T1 | 1/20 | 0.42 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11932719 | 0.80 | SCN2A (0.47) | COMTSCN2ATNKS2TNKSWNT3A | |
| SCHEMBL2433653 | 0.79 | COMT (1.00) | COMTSCN2ATRPV1TNKS2TNKS | |
| SCHEMBL7012072 | 0.78 | RECQL (0.67) | COMTSCN2ATRPV1TNKS2TNKS | |
| SCHEMBL4376727 | 0.77 | KDM4E (0.76) | COMTKDM4EL3MBTL1RAB9A | |
| SCHEMBL3586816 | 0.75 | COMT (0.68) | COMTSCN2ATRPV1TNKS2TNKS | |
| SCHEMBL23736196 | 0.74 | SCN2A (0.59) | COMTSCN2ATRPV1TNKS2TNKS | |
| SCHEMBL15331905 | 0.71 | COMT (0.57) | COMTSCN2ATRPV1TNKS2TNKS | |
| SCHEMBL26202011 | 0.71 | SCN2A (0.55) | COMTSCN2ATRPV1TNKS2TNKS | |
| SCHEMBL15693156 | 0.68 | TNKS2 (0.54) | COMTTNKS2TNKSWNT3APARP2 | |
| SCHEMBL25833757 | 0.68 | SCN2A (0.55) | SCN2ATRPV1NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7153861-B2 | For therapy of atheroscelerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2006-12-26 | — | — | US | disclosed |