Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 7/20 | 0.66 |
| ▸ | FPR1 | P21462 | 1/20 | 0.66 |
| ▸ | GPR183 | P32249 | 1/20 | 0.66 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.66 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.40 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.39 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.38 |
| ▸ | CYP26B1 | Q9NR63 | 3/20 | 0.38 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6193122 | 0.82 | GNRHR (0.70) | GNRHRFPR1GPR183GPR119S1PR4 | |
| SCHEMBL6638649 | 0.79 | GNRHR (0.63) | GNRHRFPR1GPR183GPR119S1PR4 | |
| SCHEMBL6667308 | 0.79 | GNRHR (0.68) | GNRHRFPR1GPR183GPR119S1PR4 | |
| SCHEMBL208907 | 0.79 | GNRHR (1.00) | GNRHRFPR1GPR183GPR119 | |
| SCHEMBL31060713 | 0.79 | GNRHR (1.00) | GNRHRFPR1GPR183GPR119 | |
| SCHEMBL6672165 | 0.77 | GNRHR (0.62) | GNRHRFPR1GPR183GPR119S1PR4 | |
| SCHEMBL6667334 | 0.76 | GNRHR (0.61) | GNRHRFPR1GPR183GPR119S1PR4 | |
| SCHEMBL6640103 | 0.76 | GNRHR (0.61) | GNRHRFPR1GPR183GPR119S1PR4 | |
| SCHEMBL6641037 | 0.75 | GNRHR (0.62) | GNRHRFPR1GPR183GPR119S1PR4 | |
| SCHEMBL6669367 | 0.75 | GNRHR (0.60) | GNRHRFPR1GPR183GPR119S1PR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7101878-B1 | Non-peptide GNRH agents, methods and intermediates for their preparation | AGOURON PHARMACEUTICALS, INC. (US) | 2006-09-05 | — | — | US | disclosed |
| EP-1105120-B1 | NON-PEPTIDE GnRH AGENTS, METHODS AND INTERMEDIATES FOR THEIR PREPARATION | AGOURON PHARMA (US) | 2005-03-23 | — | — | EP | disclosed |