Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 3/20 | 0.70 |
| ▸ | FPR1 | P21462 | 1/20 | 0.70 |
| ▸ | GPR183 | P32249 | 1/20 | 0.70 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.70 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.45 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.45 |
| ▸ | RXRA | P19793 | 9/20 | 0.45 |
| ▸ | RXRB | P28702 | 4/20 | 0.45 |
| ▸ | RXRG | P48443 | 4/20 | 0.45 |
| ▸ | RARA | P10276 | 1/20 | 0.45 |
| ▸ | RARB | P10826 | 1/20 | 0.45 |
| ▸ | RARG | P13631 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6667308 | 0.82 | GNRHR (0.68) | GNRHRFPR1GPR183GPR119CYP26A1 | |
| SCHEMBL31060713 | 0.82 | GNRHR (1.00) | GNRHRFPR1GPR183GPR119 | |
| SCHEMBL5834344 | 0.82 | GNRHR (0.66) | GNRHRFPR1GPR183GPR119CYP26A1 | |
| SCHEMBL208907 | 0.82 | GNRHR (1.00) | GNRHRFPR1GPR183GPR119 | |
| SCHEMBL6638649 | 0.80 | GNRHR (0.63) | GNRHRFPR1GPR183GPR119CYP26A1 | |
| SCHEMBL6672165 | 0.80 | GNRHR (0.62) | GNRHRFPR1GPR183GPR119RXRA | |
| SCHEMBL6667334 | 0.79 | GNRHR (0.61) | GNRHRFPR1GPR183GPR119CYP26A1 | |
| SCHEMBL6640103 | 0.79 | GNRHR (0.61) | GNRHRFPR1GPR183GPR119CYP26A1 | |
| SCHEMBL6641037 | 0.78 | GNRHR (0.62) | GNRHRFPR1GPR183GPR119CYP26A1 | |
| SCHEMBL6669367 | 0.78 | GNRHR (0.60) | GNRHRFPR1GPR183GPR119RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1105120-B1 | NON-PEPTIDE GnRH AGENTS, METHODS AND INTERMEDIATES FOR THEIR PREPARATION | AGOURON PHARMA (US) | 2005-03-23 | — | — | EP | disclosed |