Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.45 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 13/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7077070 | 0.85 | SIGMAR1 (0.37) | MAOASIGMAR1F10NAMPT | |
| SCHEMBL7078871 | 0.85 | SIGMAR1 (0.37) | MAOASIGMAR1F10NAMPT | |
| SCHEMBL5834431 | 0.83 | MAOA (0.47) | MAOACYP2E1SIGMAR1F10ITGB3 | |
| SCHEMBL6765247 | 0.82 | MAOA (0.45) | MAOACYP2E1SIGMAR1F10NAMPT | |
| SCHEMBL5834526 | 0.80 | MAOA (0.45) | MAOACYP2E1SIGMAR1F10ITGB3 | |
| SCHEMBL7080989 | 0.76 | MAOA (0.41) | MAOAMAOB | |
| SCHEMBL7084688 | 0.76 | MAOA (0.41) | MAOAMAOB | |
| SCHEMBL7077996 | 0.76 | MAOA (0.34) | MAOAF10MAOB | |
| SCHEMBL7076987 | 0.76 | MAOA (0.34) | MAOAF10MAOB | |
| SCHEMBL7077019 | 0.74 | CALML3 (0.49) | MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7087629-B2 | Useful activity against Gram-positive pathogens and, in particular, against various strains exhibiting resistance to vancomycin and against E. faecium strains resistant to both aminoglycosides and clinically used beta-lactams | ASTRAZENECA AB (SE) | 2006-08-08 | — | — | US | disclosed |
| US-6734200-B1 | ANTIBIOTIC COMPOUNDS CONTAINING A SUBSTITUTED OXAZOLIDINONE RING; ACTIVITY AGAINST GRAM-POSITIVE PATHOGENS | ASTRAZENECA AB (SE) | 2004-05-11 | — | — | US | disclosed |