Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL8 | P10145 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | FLT4 | P35916 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5967693 | 1.00 | CXCL8 (0.33) | CXCL8EPHX1FLT4KDRNOS2 | |
| SCHEMBL5835995 | 0.79 | PDE4D (0.32) | — | |
| SCHEMBL18895150 | 0.74 | — | — | |
| SCHEMBL10174668 | 0.73 | — | — | |
| SCHEMBL872180 | 0.68 | — | — | |
| SCHEMBL25898111 | 0.68 | TSHR (0.38) | — | |
| SCHEMBL6566363 | 0.68 | PDCD1LG2 (0.33) | — | |
| SCHEMBL25423334 | 0.68 | KMT2A (0.34) | EPHX1 | |
| SCHEMBL21436764 | 0.67 | EPHX1 (0.36) | CXCL8EPHX1FLT4NOS2 | |
| SCHEMBL5967687 | 0.67 | PDPK1 (0.36) | CXCL8EPHX1FLT4KDRNOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615697-A2 | NEW PYRAZOLO[1,5-A] PYRIMIDINE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | NOVO NORDISK A/S (DK) | 2006-01-18 | — | — | EP | disclosed |
| WO-2004089471-A2 | NEW PYRAZOLO[1,5-a] PYRIMIDINES DERIVATIVES AND PHARMACEUTICAL USE THEREOF | NOVO NORDISK A/S (DK) | 2004-10-21 | — | — | WO | disclosed |