Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CCNC | P24863 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | FLT4 | P35916 | 6/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.31 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10222482 | 0.76 | CYP2A6 (0.35) | NOS3NOS2 | |
| SCHEMBL4601709 | 0.73 | NTRK1 (0.38) | MKNK1MKNK2P2RX7NR3C2CCNC | |
| SCHEMBL28290525 | 0.72 | SIRT3 (0.43) | EPHX1CXCL8DYRK1AKMT2ACCNC | |
| SCHEMBL353138 | 0.71 | SIRT3 (0.46) | MKNK1MKNK2P2RX7CCNCCDK8 | |
| SCHEMBL10530090 | 0.71 | TSHR (0.45) | IDO1TDP1 | |
| SCHEMBL10002398 | 0.70 | CXCL8 (0.42) | EPHX1MKNK1MKNK2CXCL8P2RX7 | |
| SCHEMBL14895899 | 0.70 | IKBKB (0.49) | MKNK2CDK8LIMK1 | |
| SCHEMBL10528224 | 0.70 | CYP19A1 (0.59) | — | |
| SCHEMBL10527566 | 0.70 | TSHR (0.47) | IDO1 | |
| Hydrochloric Acid SCHEMBL5796678 | 0.69 | SIRT3 (0.44) | MKNK1MKNK2P2RX7CCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3774780-A1 | COMPOUNDS AND THEIR USE AS PDE4 ACTIVATORS | Mironid Limited (GB) | 2021-02-17 | — | — | EP | disclosed |
| WO-2019193342-A1 | COMPOUNDS AND THEIR USE AS PDE4 ACTIVATORS | MIRONID LIMITED (GB) | 2019-10-10 | — | — | WO | disclosed |