Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 4/20 | 0.72 |
| ▸ | CDK2 | P24941 | 4/20 | 0.72 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.72 |
| ▸ | CSNK1D | P48730 | 8/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | FBP1 | P09467 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | GLS | O94925 | 1/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5835387 | 0.86 | CCNE1 (0.74) | CCNE1CDK2CDK5MEN1ALDH1A1 | |
| SCHEMBL5835922 | 0.84 | CCNE1 (1.00) | CCNE1CDK2CDK5CSNK1DMEN1 | |
| SCHEMBL5835614 | 0.82 | CCNE1 (0.67) | CCNE1CDK2CDK5CSNK1DALDH1A1 | |
| SCHEMBL5835575 | 0.82 | CCNE1 (0.74) | CCNE1CDK2CDK5CSNK1DALDH1A1 | |
| SCHEMBL2753861 | 0.80 | LMNA (0.73) | CCNE1CDK2CDK5CSNK1DMEN1 | |
| SCHEMBL5836578 | 0.80 | CCNE1 (0.67) | CCNE1CDK2CDK5MEN1ALDH1A1 | |
| SCHEMBL27578137 | 0.80 | CCNE1 (0.76) | CCNE1CDK2CDK5ALDH1A1LMNA | |
| SCHEMBL5836854 | 0.78 | CCNE1 (0.77) | CCNE1CDK2CDK5MEN1ALDH1A1 | |
| SCHEMBL6287753 | 0.77 | FBP1 (0.65) | MEN1ALDH1A1KMT2AFBP1LMNA | |
| SCHEMBL5836346 | 0.75 | SMN1; SMN2 (0.65) | CCNE1CDK2CDK5MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1325389-A | 2-aminothiazole derivatives, process for preparing the same and their use as antitumor agents | PHARMACIA & UPJOHN SPA (IT) | 2001-12-05 | — | — | CN | claimed |
| US-7037929-B1 | 2-amino-thiazole derivatives, process for their preparation, and their use as antitumor agents | PHARMACIA & UPJOHN S.P.A. (IT) | 2006-05-02 | — | — | US | disclosed |
| CN-1325389-A | 2-aminothiazole derivatives, process for preparing the same and their use as antitumor agents | PHARMACIA & UPJOHN SPA (IT) | 2001-12-05 | — | — | CN | disclosed |