Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27103340 | 0.90 | ALDH1A1 (0.56) | TRPV4ALDH1A1KDM4EGAAMAPT | |
| SCHEMBL7652684 | 0.86 | ALDH1A1 (0.65) | TRPV4ALDH1A1KDM4EGAAMAPT | |
| SCHEMBL24770354 | 0.85 | TRPV4 (0.50) | TRPV4ALDH1A1KDM4EGAAMAPT | |
| SCHEMBL30016057 | 0.85 | TRPV4 (0.50) | TRPV4ALDH1A1KDM4EGAAMAPT | |
| SCHEMBL29709827 | 0.83 | TRPV4 (0.60) | TRPV4ALDH1A1KDM4EGAAMAPT | |
| SCHEMBL2496224 | 0.83 | TRPV4 (0.60) | TRPV4ALDH1A1KDM4EGAAMAPT | |
| SCHEMBL10721874 | 0.81 | KDM4E (0.52) | TRPV4ALDH1A1KDM4EGAALMNA | |
| SCHEMBL13517584 | 0.79 | TRPV4 (0.52) | TRPV4ALDH1A1KDM4EGAAMAPT | |
| SCHEMBL5835370 | 0.79 | TRPV4 (0.52) | TRPV4ALDH1A1KDM4EGAATSHR | |
| SCHEMBL10570597 | 0.78 | TRPV4 (0.59) | TRPV4ALDH1A1KDM4EGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7026349-B2 | Sulfonamides | SMITHKLINE BEECHAM CORPORATION (US) | 2006-04-11 | — | — | US | disclosed |