Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 1/20 | 0.60 |
| ▸ | CDK2 | P24941 | 1/20 | 0.60 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.55 |
| ▸ | SETD1B | Q9UPS6 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TGM2 | P21980 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5835710 | 0.85 | CCNE1 (0.61) | CCNE1CDK2CDK5HTTSMN1; SMN2 | |
| SCHEMBL5956259 | 0.84 | CCNE1 (0.67) | CCNE1CDK2CDK5HTTSMN1; SMN2 | |
| SCHEMBL5835640 | 0.82 | CCNE1 (0.59) | CCNE1CDK2CDK5HTTSMN1; SMN2 | |
| SCHEMBL5836908 | 0.81 | CCNE1 (0.55) | CCNE1CDK2CDK5HTTSMN1; SMN2 | |
| SCHEMBL5835981 | 0.80 | HTT (0.48) | CCNE1CDK2CDK5HTTSMN1; SMN2 | |
| SCHEMBL21533445 | 0.78 | SETD1B (0.65) | CCNE1CDK2CDK5SMN1; SMN2MAPK10 | |
| SCHEMBL32681311 | 0.76 | HTT (0.71) | HTTSMN1; SMN2LMNATGM2HDAC3 | |
| SCHEMBL5835922 | 0.76 | CCNE1 (1.00) | CCNE1CDK2CDK5HTTSMN1; SMN2 | |
| SCHEMBL8704472 | 0.76 | MMP3 (0.60) | HTTSMN1; SMN2LMNATGM2ALDH1A1 | |
| SCHEMBL8709704 | 0.75 | MMP3 (0.59) | HTTSMN1; SMN2LMNATGM2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7037929-B1 | 2-amino-thiazole derivatives, process for their preparation, and their use as antitumor agents | PHARMACIA & UPJOHN S.P.A. (IT) | 2006-05-02 | — | — | US | disclosed |