Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 12/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.49 |
| ▸ | TGM2 | P21980 | 1/20 | 0.48 |
| ▸ | MMP1 | P03956 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8711000 | 1.00 | MMP3 (0.59) | MMP3HTTKEAP1NFE2L2TGM2 | |
| SCHEMBL8704472 | 0.99 | MMP3 (0.60) | MMP3HTTKEAP1NFE2L2TGM2 | |
| SCHEMBL8709619 | 0.82 | MMP3 (0.54) | MMP3HTTKEAP1NFE2L2TGM2 | |
| SCHEMBL8709618 | 0.81 | SIRT5 (0.54) | MMP3MMP1 | |
| SCHEMBL6962672 | 0.81 | SIRT5 (0.54) | MMP3MMP1 | |
| SCHEMBL14264247 | 0.78 | HTT (0.64) | HTTKEAP1NFE2L2TGM2KDM4E | |
| SCHEMBL27860862 | 0.77 | HTT (0.69) | HTTKEAP1NFE2L2TGM2LMNA | |
| SCHEMBL14729295 | 0.77 | HTT (0.69) | HTTKEAP1NFE2L2TGM2LMNA | |
| SCHEMBL5835640 | 0.77 | CCNE1 (0.59) | HTTTGM2ALDH1A1SMN1; SMN2 | |
| SCHEMBL6964033 | 0.76 | MMP3 (0.55) | MMP3MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5830869-A | METALLOPROTEASE INHIBITOR | PHARMACIA & UPJOHN COMPANY | 1998-11-03 | — | — | US | disclosed |