Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Xylitol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.40 |
| ▸ | TOP1 | P11387 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ribitol SCHEMBL4316278 | 1.00 | LMNA (0.67) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Xylitol SCHEMBL190756 | 1.00 | LMNA (0.67) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Adonitol SCHEMBL27551573 | 1.00 | LMNA (0.67) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Xylitol SCHEMBL19180061 | 1.00 | LMNA (0.67) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Galactitol SCHEMBL9686277 | 0.97 | LMNA (0.73) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Sorbitol SCHEMBL31107070 | 0.93 | LMNA (0.79) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Sorbitol SCHEMBL1079506 | 0.93 | LMNA (0.79) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Mannitol SCHEMBL76098 | 0.93 | LMNA (0.79) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Mannitol SCHEMBL28035901 | 0.93 | LMNA (0.79) | LMNAL3MBTL1TDP1KDM4EPDE4A | |
| Mannitol SCHEMBL2489294 | 0.93 | LMNA (0.79) | LMNAL3MBTL1TDP1KDM4EPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1727890-A1 | MUTATED XYLOSE REDUCTASE IN XYLOSE-FERMENTATION BY S. CEREVISIAE | Forskarpatent i Syd AB (SE) | 2006-12-06 | — | — | EP | disclosed |
| WO-2005093041-A1 | MUTATED XYLOSE REDUCTASE IN XYLOSE-FERMENTATION BY S. CEREVISIAE | FORSKARPATENT I SYD AB (SE) | 2005-10-06 | — | — | WO | disclosed |