Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | FABP3 | P05413 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | RAB9A | P51151 | 2/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7050759 | 0.88 | PDCD1 (0.35) | PDCD1CD274FABP3ADRA2AADRA2B | |
| SCHEMBL5837366 | 0.87 | PDCD1 (0.33) | PDCD1CD274CHRNB2CHRNA4 | |
| SCHEMBL29366427 | 0.86 | PDCD1 (0.34) | PDCD1CD274FABP3ADRA2AADRA2B | |
| SCHEMBL7053161 | 0.86 | PDCD1 (0.34) | PDCD1CD274ADRA2AADRA2BADRA2C | |
| SCHEMBL61908 | 0.86 | PDCD1 (0.34) | PDCD1CD274FABP3ADRA2AADRA2B | |
| SCHEMBL7054636 | 0.86 | PDCD1 (0.30) | PDCD1CD274 | |
| SCHEMBL5836983 | 0.85 | CNR2 (0.30) | — | |
| SCHEMBL7053136 | 0.84 | PDCD1 (0.35) | PDCD1CD274FABP3ADRA2AADRA2B | |
| SCHEMBL7048706 | 0.84 | PDCD1 (0.31) | PDCD1CD274CHRNB2CHRNA4 | |
| SCHEMBL6453883 | 0.84 | PDCD1 (0.33) | PDCD1CD274ADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6984743-B1 | Method for producing metallocenes | BASELL POLYOLEFINE GMBH (DE) | 2006-01-10 | — | — | US | disclosed |
| US-6620953-B1 | Complexing dimethylbis(2-methyl-4,5-benzoindenyl)silane with transition metal compounds such as 2,4-di-tert-butylphenoxide, zirconium monochloride, to form polymerization catalysts | BASSELL POLYOLEFINE GMBH (DE) | 2003-09-16 | — | — | US | disclosed |
| EP-0985674-B1 | ORGANIC COMPOUNDS CONTAINING SILICON OR GERMANIUM, TRANSITION METAL COMPLEXES, CATALYST FOR ALPHA-OLEFIN POLYMERIZATION, AND PROCESSES FOR PRODUCING ALPHA-OLEFIN POLYMERS | MITSUBISHI CHEM CORP (JP) | 2003-04-23 | — | — | EP | disclosed |
| EP-1015463-B1 | METHOD FOR PRODUCING METALLOCENES | BASELL POLYOLEFINE GMBH (DE) | 2002-12-11 | — | — | EP | disclosed |
| EP-0790076-B1 | Catalysts containing metallocenes with arylsubstituted indenyl derivatives as ligands, process and intermediates for the preparation of these metallocenes and their use | BASELL POLYOLEFINE GMBH (DE) | 2001-12-05 | — | — | EP | disclosed |
| US-20010021755-A1 | Metallocenes containing aryl-substituted indenyl derivatives as ligands, process for their preparation, and their use as catalysts | KUBER FRANK (DE) | 2001-09-13 | — | — | US | disclosed |
| US-6255506-B1 | SUPPORTED SYSTEM IN POLYMERIZATION OR COPOLYMERIZATION OF HIGH MOLECULAR WEIGHT POLYOLEFINS OF HIGH ISOTACTICITY AND NARROW MOLECULAR-WEIGHT DISTRIBUTION; FILMS, SHEETS OR LARGE HOLLOW ARTICLES OR MOLDINGS | TARGOR GMBH (DE) | 2001-07-03 | — | — | US | disclosed |
| US-6255515-B1 | COORDINATION POLYMERIZATION CATALYSTS | MITSUBISHI CHEMICAL CORPORATION (JP) | 2001-07-03 | — | — | US | disclosed |
| US-6242544-B1 | POLYOLEFINS PREPARED USING SOLUBLE METALLOCENE COMPOUNDS IN COMBINATION WITH ALUMINOXANES; HIGH MOLECULAR WEIGHT AND ISOTACTICITY | TARGOR GMBH (DE) | 2001-06-05 | — | — | US | disclosed |
| EP-1015463-A1 | METHOD FOR PRODUCING METALLOCENES | Basell Polyolefine GmbH (DE) | 2000-07-05 | — | — | EP | disclosed |
| US-6051727-A | A POLYMERIZATION CATALYST FOR POLYOLEFINS OF HIGH MOLECULAR WEIGHT, OF PARTICULAR IMPORTANCE FOR THE PRODUCTION OF FILMS, SHEETS OR LARGE HOLLOW ARTICLES OR MOLDINGS SUCH AS PIPES | TARGOR GMBH (DE) | 2000-04-18 | — | — | US | disclosed |
| WO-1999012943-A1 | METHOD FOR PRODUCING METALLOCENES | TARGOR GMBH (DE) | 1999-03-18 | — | — | WO | disclosed |
| US-5840644-A | OLEFIN POLYMERIZATION CATALYSTS | TARGOR GMBH (DE) | 1998-11-24 | — | — | US | disclosed |
| US-5786432-A | POLYMERIZING OR COPOLYMERIZING OLEFIN IN PRESENCE OF TRANSITION METAL METALLOCENE CATALYST AND COCATALYST | TARGOR GMBH (DE) | 1998-07-28 | — | — | US | disclosed |
| US-5770753-A | ADDITION POLYMERIZATION CATALYST | TARGOR GMBH (DE) | 1998-06-23 | — | — | US | disclosed |
| EP-0576970-B1 | Metallocenes with arylsubstituted indenyl-derivatives as ligands, process for their preparation and their use as catalysts | HOECHST AG (DE) | 1998-01-14 | — | — | EP | disclosed |
| EP-0790076-A2 | Catalysts containing metallocenes with arylsubstituted indenyl derivatives as ligands, process and intermediates for the preparation of these metallocenes and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-08-20 | — | — | EP | disclosed |
| EP-0576970-A1 | Metallocenes with arylsubstituted indenyl-derivatives as ligands, process for their preparation and their use as catalysts | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-01-05 | — | — | EP | disclosed |