Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 1/20 | 0.49 |
| ▸ | CTSS | P25774 | 5/20 | 0.49 |
| ▸ | CTSK | P43235 | 4/20 | 0.49 |
| ▸ | CTSB | P07858 | 2/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5841164 | 1.00 | ADORA1 (0.49) | ADORA1CTSSCTSKCTSBCTSL | |
| SCHEMBL5838097 | 0.87 | CTSS (0.45) | ADORA1CTSSCTSKCTSBCTSL | |
| SCHEMBL7475249 | 0.86 | CTSS (0.44) | ADORA1CTSSCTSKCTSBCTSL | |
| SCHEMBL5842061 | 0.86 | CTSS (0.44) | ADORA1CTSSCTSKCTSBCTSL | |
| SCHEMBL6317021 | 0.78 | ADORA1 (0.35) | ADORA1KMT2AMEN1 | |
| SCHEMBL5838379 | 0.78 | CTSS (0.32) | ADORA1CTSSCTSKATMKMT2A | |
| SCHEMBL5838350 | 0.73 | ADORA1 (0.38) | ADORA1KMT2AMEN1 | |
| SCHEMBL5837844 | 0.72 | HPGD (0.46) | KMT2AMEN1 | |
| SCHEMBL5838074 | 0.71 | GRM6 (0.39) | ADORA1KMT2AMEN1 | |
| SCHEMBL21010315 | 0.70 | CTSS (0.79) | CTSSCTSKCTSBCTSLAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115624-B1 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2006-10-03 | — | — | US | disclosed |
| US-7019026-B1 | Modulators of Protein Tyrosine Phosphatases (PTPases) | NOVO NORDISK A/S (DK) | 2006-03-28 | — | — | US | disclosed |
| EP-1214325-B1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK AS (DK) | 2005-11-09 | — | — | EP | disclosed |