SCHEMBL5837474

SCHEMBL5837474

COCC1(COC)c2ccccc2C=Cc2ccccc21

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.39
PKM P14618 1/20 0.39
P2RX4 Q99571 2/20 0.35
KIF11 P52732 2/20 0.34
GAA P10253 1/20 0.33
MAPT P10636 1/20 0.33
SIGMAR1 Q99720 1/20 0.30
CYP1A2 P05177 2/20 0.30
RET P07949 2/20 0.30
CYP2D6 P10635 2/20 0.30
MCHR2 Q969V1 1/20 0.30
TP53 P04637 1/20 0.30
CHRM2 P08172 1/20 0.30
HTR1A P08908 1/20 0.30
CHRM1 P11229 1/20 0.30
DRD2 P14416 1/20 0.30
ALOX15 P16050 1/20 0.30
TSHR P16473 1/20 0.30
ADRA2C P18825 1/20 0.30
CHRM3 P20309 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29415598 0.78 APEX1 (0.42) KDM4EMAPTCYP1A2CYP2D6TP53
SCHEMBL233774 0.78 APEX1 (0.42) KDM4EMAPTCYP1A2CYP2D6TP53
Lithium SCHEMBL31124519 0.77 APEX1 (0.41) KDM4EMAPTCYP1A2CYP2D6TP53
SCHEMBL811773 0.76 KDM4E (0.33) KDM4EPKMP2RX4KIF11MCHR2
SCHEMBL29481548 0.76 KDM4E (0.33) KDM4EPKMP2RX4KIF11MCHR2
SCHEMBL813158 0.74 ESR1 (0.38)
SCHEMBL29481535 0.74 ESR1 (0.38)
SCHEMBL4576869 0.73 HTR2A (0.50) DRD2SLC6A2HTR2AHTR2CSLC6A4
SCHEMBL31538816 0.73 HTR2A (0.50) DRD2SLC6A2HTR2AHTR2CSLC6A4
SCHEMBL5836205 0.73 P2RX4 (0.37) P2RX4CHRM3CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10308563-B2 Process for producing ethylene oligomers HANWHA TOTAL PETROCHEMICAL CO., LTD. (KR) 2019-06-04 US disclosed
US-20180170827-A1 PROCESS FOR PRODUCING ETHYLENE OLIGOMERS HANWHA TOTALENERGIES PETROCHEMICAL CO., LTD. (KR) 2018-06-21 US disclosed
US-20180169642-A1 CATALYST SYSTEM FOR ETHYLENE OLIGOMERIZATION AND METHOD FOR PRODUCING ETHYLENE OLIGOMERIZATION USING THE SAME HANWHA TOTAL PETROCHEMICAL CO., LTD. (KR) 2018-06-21 US disclosed
US-7049377-B1 1,3-diethers and components and catalysts for the polymerization of olefins, containing said diethers BASELL POLIOLEFINE ITALIA S.R.L. (IT) 2006-05-23 US disclosed
US-7022640-B2 1,3-diethers and components and catalysts for the polymerization of olefins, containing said diethers BASELL POLIOLEFINE ITALIA S.R.L. (IT) 2006-04-04 US disclosed
US-20040235645-A1 1,3-Diethers and components and catalysts for the polymerization of olefins, containing said diethers MORINI GIAMPIERO (IT) 2004-11-25 US disclosed
EP-0728770-B1 Process for the preparation of solid catalyst components for the polymerization of olefins MONTELL NORTH AMERICA INC (US) 1999-07-14 EP disclosed
EP-0728769-B1 Components and catalysts for the polymerization of olefins MONTELL NORTH AMERICA INC (US) 1998-08-19 EP disclosed
EP-0728770-A1 Process for the preparation of solid catalyst components for the polymerization of olefins MONTELL NORTH AMERICA INC. (US) 1996-08-28 EP disclosed
EP-0728724-A1 Diethers suitable for use in the preparation of Ziegler-Natta catalysts MONTELL NORTH AMERICA INC. (US) 1996-08-28 EP disclosed
EP-0728769-A1 Components and catalysts for the polymerization of olefins MONTELL NORTH AMERICA INC. (US) 1996-08-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10308563-B2 Process for producing ethylene oligomers OXER1, HAO2, ORC3 KDM4E 3585/4885PKM 3641/4885P2RX4 3299/4885
US-20180169642-A1 CATALYST SYSTEM FOR ETHYLENE OLIGOMERIZATION AND METHOD FOR PRODUCING ETHYLENE OLIGOMERIZATION USING THE SAME HACL2, HAO2, MSMO1 KDM4E 4218/4885PKM 3156/4885P2RX4 3980/4885
US-20180170827-A1 PROCESS FOR PRODUCING ETHYLENE OLIGOMERS OXER1, HAO2, ORC3 KDM4E 3585/4885PKM 3641/4885P2RX4 3299/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.