Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GRM6 | O15303 | 1/20 | 0.33 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.33 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5838694 | 0.90 | GRM6 (0.33) | MAPTKDM4EGRM6CXCR2ADORA1 | |
| SCHEMBL5838665 | 0.87 | ADORA1 (0.33) | MAPTKDM4EGRM6ADORA1 | |
| SCHEMBL5838246 | 0.87 | CXCR2 (0.39) | MAPTCXCR2ALDH1A1 | |
| SCHEMBL5838372 | 0.86 | GRM6 (0.37) | MAPTKDM4EGRM6CXCR2ADORA1 | |
| SCHEMBL6316682 | 0.81 | GRM6 (0.40) | MAPTKDM4EGRM6CXCR2ADORA1 | |
| SCHEMBL6316465 | 0.80 | KDM4E (0.34) | MAPTKDM4EGRM6ADORA1ALDH1A1 | |
| SCHEMBL5837781 | 0.78 | GABRA1 (0.37) | MAPTKDM4EADORA1 | |
| SCHEMBL5838623 | 0.77 | CXCR2 (0.38) | MAPTCXCR2ALDH1A1 | |
| SCHEMBL6316776 | 0.77 | ADORA1 (0.36) | MAPTKDM4EADORA1ALDH1A1GAA | |
| SCHEMBL5838591 | 0.77 | ALDH1A1 (0.38) | MAPTCXCR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115624-B1 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2006-10-03 | — | — | US | disclosed |
| US-7019026-B1 | Modulators of Protein Tyrosine Phosphatases (PTPases) | NOVO NORDISK A/S (DK) | 2006-03-28 | — | — | US | disclosed |
| EP-1214325-B1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK AS (DK) | 2005-11-09 | — | — | EP | disclosed |