Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN2 | P17706 | 3/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.37 |
| ▸ | NT5E | P21589 | 1/20 | 0.35 |
| ▸ | GHSR | Q92847 | 5/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.32 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5837464 | 0.88 | ADORA1 (0.35) | NT5EGHSRCARM1HTTPTK2 | |
| SCHEMBL5838317 | 0.88 | CXCR2 (0.33) | NT5ECXCR2 | |
| SCHEMBL5838518 | 0.86 | CXCR2 (0.36) | PTPN2PTPN1NT5EL3MBTL1CXCR2 | |
| SCHEMBL5838102 | 0.85 | PTPN1 (0.38) | PTPN2PTPN1NT5EL3MBTL1CXCR2 | |
| SCHEMBL5838591 | 0.82 | ALDH1A1 (0.38) | PTPN2PTPN1NT5EL3MBTL1CXCR2 | |
| SCHEMBL5837965 | 0.80 | PTPN2 (0.34) | PTPN2PTPN1NT5ECXCR2HTT | |
| SCHEMBL5837976 | 0.77 | CXCR2 (0.33) | PTPN2PTPN1NT5ECXCR2 | |
| SCHEMBL5838606 | 0.74 | ADORA1 (0.36) | PTK2 | |
| SCHEMBL7521804 | 0.73 | NT5E (0.37) | NT5EL3MBTL1CXCR2 | |
| SCHEMBL5838939 | 0.72 | CXCR2 (0.36) | NT5ECXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115624-B1 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2006-10-03 | — | — | US | disclosed |
| EP-1214324-B1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK AS (DK) | 2006-06-14 | — | — | EP | disclosed |
| US-6410556-B1 | ANTIDIABETIC AGENTS | NOVO NORDISK A/S (DK) | 2002-06-25 | — | — | US | disclosed |
| EP-1214324-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001019830-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2001-03-22 | — | — | WO | disclosed |