Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.32 |
| ▸ | GAA | P10253 | 5/20 | 0.32 |
| ▸ | GRM6 | O15303 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 6/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5838384 | 0.91 | ALDH1A1 (0.35) | ADORA1ALDH1A1GRM6KDM4EHPGD | |
| SCHEMBL5838365 | 0.86 | CYP1A2 (0.40) | ADORA1ALDH1A1GAAGRM6MAPT | |
| SCHEMBL5838142 | 0.85 | ADORA1 (0.38) | ADORA1ALDH1A1GAAGRM6MAPT | |
| SCHEMBL6316763 | 0.85 | ALDH1A1 (0.39) | ADORA1ALDH1A1GAAMAPTKDM4E | |
| SCHEMBL6316462 | 0.84 | ADORA1 (0.35) | ADORA1ALDH1A1GAAGRM6MAPT | |
| SCHEMBL5838538 | 0.84 | CXCR2 (0.37) | ALDH1A1MAPTKDM4EHPGDTSHR | |
| SCHEMBL5838574 | 0.81 | ALDH1A1 (0.41) | ALDH1A1GAAMAPTKDM4EHSD17B10 | |
| SCHEMBL5837768 | 0.81 | ALDH1A1 (0.45) | ALDH1A1GAAHSD17B10TSHRMEN1 | |
| SCHEMBL5838682 | 0.80 | HPGD (0.33) | ADORA1ALDH1A1GRM6MAPTKDM4E | |
| SCHEMBL5837601 | 0.80 | MEN1 (0.35) | ADORA1ALDH1A1GAAGRM6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115624-B1 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2006-10-03 | — | — | US | disclosed |
| US-7019026-B1 | Modulators of Protein Tyrosine Phosphatases (PTPases) | NOVO NORDISK A/S (DK) | 2006-03-28 | — | — | US | disclosed |
| EP-1214325-B1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK AS (DK) | 2005-11-09 | — | — | EP | disclosed |
| EP-1214325-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001019831-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2001-03-22 | — | — | WO | disclosed |