Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 10/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | TSPO | P30536 | 1/20 | 0.33 |
| ▸ | RAB7A | P51149 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5838589 | 0.92 | CXCR2 (0.37) | CXCR2ALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL5837759 | 0.84 | ADORA1 (0.36) | ALDH1A1MAPTNPSR1KDM4EHPGD | |
| SCHEMBL5837378 | 0.83 | ALDH1A1 (0.44) | ALDH1A1TSHR | |
| SCHEMBL5838269 | 0.82 | PTPN1 (0.44) | PTPN1RAB7A | |
| SCHEMBL5837569 | 0.81 | CXCR2 (0.42) | CXCR2ALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL5838604 | 0.81 | CXCR2 (0.34) | CXCR2ALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL5838393 | 0.80 | CXCR2 (0.41) | CXCR2ALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL5837565 | 0.77 | GPR119 (0.33) | CXCR2ALDH1A1MAPTTSHR | |
| SCHEMBL5838384 | 0.76 | ALDH1A1 (0.35) | ALDH1A1SMN1; SMN2KDM4EHPGDTSHR | |
| SCHEMBL6314950 | 0.75 | CXCR2 (0.46) | CXCR2ALDH1A1MAPTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115624-B1 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2006-10-03 | — | — | US | disclosed |
| US-7019026-B1 | Modulators of Protein Tyrosine Phosphatases (PTPases) | NOVO NORDISK A/S (DK) | 2006-03-28 | — | — | US | disclosed |
| EP-1214325-B1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK AS (DK) | 2005-11-09 | — | — | EP | disclosed |
| EP-1214325-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001019831-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2001-03-22 | — | — | WO | disclosed |