Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.59 |
| ▸ | MAOB | P27338 | 7/20 | 0.58 |
| ▸ | MAOA | P21397 | 6/20 | 0.58 |
| ▸ | PARP1 | P09874 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CASP7 | P55210 | 2/20 | 0.50 |
| ▸ | EGFR | P00533 | 2/20 | 0.50 |
| ▸ | SRC | P12931 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | RGS12 | O14924 | 1/20 | 0.50 |
| ▸ | GMNN | O75496 | 1/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | PRKCG | P05129 | 1/20 | 0.50 |
| ▸ | PRKCB | P05771 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29540906 | 0.97 | GSK3B (0.62) | GSK3BMAOBMAOAPARP1NPSR1 | |
| SCHEMBL699461 | 0.97 | GSK3B (0.62) | GSK3BMAOBMAOAPARP1NPSR1 | |
| SCHEMBL29783117 | 0.97 | GSK3B (0.62) | GSK3BMAOBMAOAPARP1NPSR1 | |
| SCHEMBL3085755 | 0.93 | GSK3B (0.56) | GSK3BMAOBMAOAPARP1NPSR1 | |
| SCHEMBL18908888 | 0.82 | PARP1 (0.57) | GSK3BMAOBMAOAPARP1NPSR1 | |
| SCHEMBL17346927 | 0.81 | ACVR1 (0.50) | GSK3BMAOBMAOAPARP1MEN1 | |
| Phthalimide SCHEMBL28134165 | 0.79 | GSK3B (0.83) | GSK3BMAOBMAOAPARP1NPSR1 | |
| Phthalimide SCHEMBL9229 | 0.78 | GSK3B (0.94) | GSK3BMAOBMAOAPARP1NPSR1 | |
| Phthalimide SCHEMBL1205291 | 0.78 | GSK3B (0.94) | GSK3BMAOBMAOAPARP1NPSR1 | |
| Phthalimide SCHEMBL10592849 | 0.76 | GSK3B (0.88) | GSK3BMAOBMAOAPARP1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115624-B1 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2006-10-03 | — | — | US | disclosed |
| US-7019026-B1 | Modulators of Protein Tyrosine Phosphatases (PTPases) | NOVO NORDISK A/S (DK) | 2006-03-28 | — | — | US | disclosed |
| EP-1214325-B1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK AS (DK) | 2005-11-09 | — | — | EP | disclosed |