Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.62 |
| ▸ | MAOB | P27338 | 7/20 | 0.60 |
| ▸ | MAOA | P21397 | 6/20 | 0.60 |
| ▸ | PARP1 | P09874 | 1/20 | 0.56 |
| ▸ | CASP7 | P55210 | 2/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
| ▸ | CASP2 | P42575 | 1/20 | 0.52 |
| ▸ | CASP6 | P55212 | 1/20 | 0.52 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | EGFR | P00533 | 2/20 | 0.52 |
| ▸ | SRC | P12931 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | RGS12 | O14924 | 1/20 | 0.52 |
| ▸ | GMNN | O75496 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL699461 | 1.00 | GSK3B (0.62) | GSK3BMAOBMAOAPARP1CASP7 | |
| SCHEMBL29783117 | 1.00 | GSK3B (0.62) | GSK3BMAOBMAOAPARP1CASP7 | |
| SCHEMBL5838151 | 0.97 | GSK3B (0.59) | GSK3BMAOBMAOAPARP1CASP7 | |
| SCHEMBL3085755 | 0.95 | GSK3B (0.56) | GSK3BMAOBMAOAPARP1CASP7 | |
| SCHEMBL18908888 | 0.84 | PARP1 (0.57) | GSK3BMAOBMAOAPARP1CASP7 | |
| SCHEMBL17346927 | 0.83 | ACVR1 (0.50) | GSK3BMAOBMAOAPARP1CASP7 | |
| Phthalimide SCHEMBL28134165 | 0.81 | GSK3B (0.83) | GSK3BMAOBMAOAPARP1CASP7 | |
| Phthalimide SCHEMBL64 | 0.77 | GSK3B (1.00) | GSK3BMAOBMAOAPARP1CASP7 | |
| Phthalimide SCHEMBL11040503 | 0.77 | GSK3B (1.00) | GSK3BMAOBMAOAPARP1CASP7 | |
| Phthalimide SCHEMBL29366030 | 0.77 | GSK3B (1.00) | GSK3BMAOBMAOAPARP1CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12122742-B2 | Small molecule direct inhibitors of KEAP1-NRF2 protein-protein interaction | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2024-10-22 | — | — | US | disclosed |
| CN-112673011-B | Polymer for use in electronic devices | 杜邦电子公司 | 2024-08-06 | — | — | CN | disclosed |
| CN-115677442-B | Method for synthesizing alkylaryl alkyne compound by photocatalysis | 化学与精细化工广东省实验室 | 2024-05-10 | — | — | CN | disclosed |
| US-20220112160-A1 | SMALL MOLECULE DIRECT INHIBITORS OF KEAP1-NRF2 PROTEIN-PROTEIN INTERACTION | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2022-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220112160-A1 | SMALL MOLECULE DIRECT INHIBITORS OF KEAP1-NRF2 PROTEIN-PROTEIN INTERACTION | KEAP1, NFE2L2, HMOX1 | GSK3B 288/4885MAOB 2406/4885MAOA 1833/4885 |
| US-12122742-B2 | Small molecule direct inhibitors of KEAP1-NRF2 protein-protein interaction | KEAP1, NFE2L2, HMOX1 | GSK3B 288/4885MAOB 2406/4885MAOA 1833/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.