Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | FABP4 | P15090 | 5/20 | 0.54 |
| ▸ | FABP5 | Q01469 | 5/20 | 0.54 |
| ▸ | FABP3 | P05413 | 2/20 | 0.54 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.53 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.51 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1647440 | 0.85 | LRRK2 (0.62) | TP53HTTFABP4FABP5MCL1 | |
| SCHEMBL5839199 | 0.82 | FOLH1 (0.56) | MCL1PTGER1ALDH1A1LRRK2SMN1; SMN2 | |
| SCHEMBL5663261 | 0.81 | FABP4 (0.74) | TP53HTTFABP4FABP5FABP3 | |
| SCHEMBL3806442 | 0.79 | MRGPRX4 (0.71) | TP53HTTFABP4FABP5FABP3 | |
| SCHEMBL1388155 | 0.78 | HTT (0.77) | TP53HTTFABP4FABP5FABP3 | |
| SCHEMBL5662630 | 0.76 | TP53 (0.74) | TP53HTTFABP4FABP5FABP3 | |
| SCHEMBL2292252 | 0.76 | TP53 (0.62) | TP53HTTFABP4FABP5FABP3 | |
| SCHEMBL5838291 | 0.75 | FABP4 (0.59) | TP53HTTFABP4FABP5FABP3 | |
| SCHEMBL5840313 | 0.75 | FABP4 (0.65) | TP53HTTFABP4FABP5FABP3 | |
| SCHEMBL1648024 | 0.74 | LRRK2 (0.59) | TP53HTTFABP4FABP5MRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6984645-B2 | Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-01-10 | — | — | US | disclosed |
| US-20030225091-A1 | Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein | BRISTOL-MYERS SQUIBB COMPANY | 2003-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030225091-A1 | Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein | FABP4, FABP2, FABP1 | TP53 4348/4885HTT 4810/4885FABP4 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.