Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC3 | O15438 | 1/20 | 0.54 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.54 |
| ▸ | PGR | P06401 | 1/20 | 0.54 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.54 |
| ▸ | HTR2B | P41595 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.54 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.54 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.49 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7385703 | 0.94 | ABCC3 (0.58) | ABCC3ABCC4ABCB11PGRABCB1 | |
| SCHEMBL5370410 | 0.94 | ABCC3 (0.58) | ABCC3ABCC4ABCB11PGRABCB1 | |
| SCHEMBL5368677 | 0.89 | KLK5 (0.55) | ABCC3ABCC4ABCB11PGRABCB1 | |
| SCHEMBL7152588 | 0.89 | KLK5 (0.55) | ABCC3ABCC4ABCB11PGRABCB1 | |
| SCHEMBL5838875 | 0.88 | ABCC3 (0.54) | ABCC3ABCC4ABCB11PGRABCB1 | |
| SCHEMBL5369113 | 0.86 | KLK5 (0.50) | ABCC3ABCC4ABCB11PGRABCB1 | |
| SCHEMBL22305240 | 0.85 | CYP3A4 (0.50) | ABCC3ABCC4ABCB11PGRABCB1 | |
| SCHEMBL5839184 | 0.85 | ABCC3 (0.53) | ABCC3ABCC4ABCB11PGRABCB1 | |
| SCHEMBL5373893 | 0.84 | CYP3A4 (0.51) | ABCC3ABCC4ABCB11PGRABCB1 | |
| SCHEMBL30261823 | 0.84 | ABCC3 (0.65) | ABCC3ABCC4ABCB11PGRABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7132420-B2 | Aspartic protease inhibitors | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2006-11-07 | — | — | US | disclosed |
| EP-1140846-B1 | ASPARTIC PROTEASE INHIBITORS | US GOV HEALTH & HUMAN SERV (US) | 2006-04-05 | — | — | EP | disclosed |
| US-20050090546-A1 | Aspartic protease inhibitors | GOVERNMENT OF THE USA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2005-04-28 | — | — | US | disclosed |
| US-6613764-B1 | Compounds such as N,N-dibenzylphenylalanine benzyl ester, used as enzyme inhibitors; prophylaxis of lymphadenopathy associated virus, cancer and malaria | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2003-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050090546-A1 | Aspartic protease inhibitors | DPP7, SENP7, DNPEP | ABCC3 1990/4885ABCC4 2477/4885ABCB11 2323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.