Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 3/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.55 |
| ▸ | PDE4A | P27815 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 4/20 | 0.43 |
| ▸ | CNR1 | P21554 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5747125 | 0.93 | TAS1R3 (0.50) | PDE4BPDE4DPDE4AL3MBTL1RAB9A | |
| SCHEMBL5840316 | 0.91 | CNR2 (0.48) | PDE4BPDE4DPDE4AL3MBTL1RAB9A | |
| SCHEMBL5748019 | 0.87 | PDE4B (0.74) | PDE4BPDE4DPDE4AKCNH2 | |
| SCHEMBL5753703 | 0.87 | RAB9A (0.47) | PDE4BPDE4DL3MBTL1RAB9ACNR2 | |
| SCHEMBL5753712 | 0.87 | RAB9A (0.47) | PDE4BPDE4DL3MBTL1RAB9ACNR2 | |
| SCHEMBL8319888 | 0.86 | RAB9A (0.47) | PDE4BPDE4DL3MBTL1RAB9ACNR2 | |
| SCHEMBL5750322 | 0.86 | RAB9A (0.59) | RAB9ACNR2CNR1GAAMEN1 | |
| Hydrochloric Acid SCHEMBL5751702 | 0.85 | RAB9A (0.46) | PDE4BPDE4DL3MBTL1RAB9ACNR2 | |
| Hydrochloric Acid SCHEMBL5751698 | 0.85 | RAB9A (0.46) | PDE4BPDE4DL3MBTL1RAB9ACNR2 | |
| SCHEMBL5841178 | 0.85 | AURKA (0.47) | PDE4BPDE4DL3MBTL1RAB9ACNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7141586-B2 | Nicotinamide derivatives useful as PDE4 inhibitors | PFIZER INC. (US) | 2006-11-28 | — | — | US | disclosed |
| US-20050032838-A1 | Nicotinamide derivatives useful as PDE4 inhibitors | PFIZER INC. | 2005-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050032838-A1 | Nicotinamide derivatives useful as PDE4 inhibitors | CBR3, CBR1, PDE9A | PDE4B 8/4885PDE4D 72/4885PDE4A 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.