Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 12/20 | 0.72 |
| ▸ | CDK5R1 | Q15078 | 12/20 | 0.72 |
| ▸ | CCNA2 | P20248 | 10/20 | 0.72 |
| ▸ | CDK2 | P24941 | 10/20 | 0.72 |
| ▸ | CCNA1 | P78396 | 10/20 | 0.72 |
| ▸ | DYRK1A | Q13627 | 9/20 | 0.69 |
| ▸ | NPC1 | O15118 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | CDK1 | P06493 | 6/20 | 0.57 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.57 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.57 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.56 |
| ▸ | MERTK | Q12866 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | PAK4 | O96013 | 1/20 | 0.54 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29444630 | 0.88 | CDK5 (0.74) | CDK5CDK5R1CCNA2CDK2CCNA1 | |
| SCHEMBL5840458 | 0.88 | CDK5 (0.74) | CDK5CDK5R1CCNA2CDK2CCNA1 | |
| SCHEMBL20549706 | 0.87 | CDK5 (0.73) | CDK5CDK5R1CCNA2CDK2CCNA1 | |
| SCHEMBL5839686 | 0.86 | CDK5 (0.76) | CDK5CDK5R1CCNA2CDK2CCNA1 | |
| SCHEMBL5827777 | 0.86 | CDK5 (0.79) | CDK5CDK5R1CCNA2CDK2CCNA1 | |
| SCHEMBL5839709 | 0.84 | CDK5 (0.69) | CDK5CDK5R1CCNA2CDK2CCNA1 | |
| SCHEMBL17212873 | 0.84 | CDK5 (1.00) | CDK5CDK5R1CCNA2CDK2CCNA1 | |
| SCHEMBL17212874 | 0.82 | CDK5 (1.00) | CDK5CDK5R1CCNA2CDK2CCNA1 | |
| SCHEMBL4489273 | 0.82 | CDK5 (0.66) | CDK5CDK5R1CCNA2CDK2CCNA1 | |
| SCHEMBL5840317 | 0.82 | CDK1 (0.68) | CDK5CDK5R1CCNA2CDK2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7091346-B1 | Purine derivatives and processes for their preparation | NOVARTIS AG (CH) | 2006-08-15 | — | — | US | disclosed |
| EP-0874846-B1 | PURINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | NOVARTIS AG (CH) | 2003-04-02 | — | — | EP | disclosed |
| CN-1066147-C | Purine derivatives and process for preparing same | 诺瓦提斯公司 | 2001-05-23 | — | — | CN | disclosed |
| CN-1202896-A | Purine derivatives and processes for their preparation | 诺瓦提斯公司 | 1998-12-23 | — | — | CN | disclosed |
| EP-0874846-A1 | PURINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | Novartis AG (CH) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997016452-A1 | PURINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | NOVARTIS AG (CH) | 1997-05-09 | — | — | WO | disclosed |