Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 12/20 | 0.76 |
| ▸ | CDK5R1 | Q15078 | 12/20 | 0.76 |
| ▸ | CDK2 | P24941 | 11/20 | 0.76 |
| ▸ | CCNA2 | P20248 | 10/20 | 0.76 |
| ▸ | CCNA1 | P78396 | 10/20 | 0.76 |
| ▸ | DYRK1A | Q13627 | 9/20 | 0.76 |
| ▸ | NPC1 | O15118 | 1/20 | 0.71 |
| ▸ | POLB | P06746 | 1/20 | 0.71 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.58 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.58 |
| ▸ | CDK1 | P06493 | 4/20 | 0.57 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28771433 | 0.88 | CDK2 (0.76) | CDK5CDK5R1CDK2CCNA2CCNA1 | |
| SCHEMBL5827777 | 0.87 | CDK5 (0.79) | CDK5CDK5R1CDK2CCNA2CCNA1 | |
| SCHEMBL5839477 | 0.86 | CDK5 (0.72) | CDK5CDK5R1CDK2CCNA2CCNA1 | |
| SCHEMBL17212875 | 0.83 | CDK5 (0.78) | CDK5CDK5R1CDK2CCNA2CCNA1 | |
| SCHEMBL31307877 | 0.83 | CDK5 (1.00) | CDK5CDK5R1CDK2CCNA2CCNA1 | |
| SCHEMBL23494096 | 0.83 | CDK5 (1.00) | CDK5CDK5R1CDK2CCNA2CCNA1 | |
| SCHEMBL183282 | 0.83 | YTHDC1 (0.61) | CDK5CDK5R1CDK2CCNA2CCNA1 | |
| SCHEMBL17212872 | 0.82 | CDK5 (1.00) | CDK5CDK5R1CDK2CCNA2CCNA1 | |
| SCHEMBL5839079 | 0.82 | CDK5 (0.68) | CDK5CDK5R1CDK2CCNA2CCNA1 | |
| SCHEMBL28459824 | 0.82 | CDK1 (0.79) | CDK5CDK5R1CDK2CCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7091346-B1 | Purine derivatives and processes for their preparation | NOVARTIS AG (CH) | 2006-08-15 | — | — | US | disclosed |
| EP-0874846-B1 | PURINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | NOVARTIS AG (CH) | 2003-04-02 | — | — | EP | disclosed |
| CN-1066147-C | Purine derivatives and process for preparing same | 诺瓦提斯公司 | 2001-05-23 | — | — | CN | disclosed |
| CN-1202896-A | Purine derivatives and processes for their preparation | 诺瓦提斯公司 | 1998-12-23 | — | — | CN | disclosed |
| EP-0874846-A1 | PURINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | Novartis AG (CH) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997016452-A1 | PURINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | NOVARTIS AG (CH) | 1997-05-09 | — | — | WO | disclosed |