Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24475840 | 0.89 | PPARD (0.54) | PPARDTSHRTP53ALOX15TDP1 | |
| SCHEMBL9819300 | 0.83 | PPARD (0.38) | PPARDTP53MEN1FAAHCYP1A2 | |
| SCHEMBL4583907 | 0.80 | CYP3A4 (0.47) | TSHRTP53MEN1FAAHCYP1A2 | |
| SCHEMBL2991834 | 0.80 | PPARD (0.58) | PPARDTSHRTP53TDP1CA12 | |
| SCHEMBL1276434 | 0.80 | PPARD (0.58) | PPARDTSHRTP53TDP1CA12 | |
| SCHEMBL11595192 | 0.79 | PPARD (0.47) | PPARDTSHRTP53ALOX15TDP1 | |
| SCHEMBL28021210 | 0.78 | PPARD (0.56) | PPARDTSHRTP53TDP1CA12 | |
| SCHEMBL7922676 | 0.78 | PPARD (0.56) | PPARDTSHRTP53TDP1CA12 | |
| SCHEMBL7425644 | 0.78 | PPARD (0.56) | PPARDTSHRTP53TDP1CA12 | |
| SCHEMBL11596171 | 0.78 | PPARD (0.50) | PPARDTSHRTP53TDP1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4585703-A | MELAMINE RESIN AND PHOSPHONATE FIREPROOFING AGENT | DAINIPPON INK & CHEMICALS, INC. (JP) | 1986-04-29 | — | — | US | claimed |
| US-4451262-A | After-treatment of finished, cellulose-containing fibrous materials with liquid ammonia | CIBA-GEIGY CORPORATION (US) | 1984-05-29 | — | — | US | claimed |
| EP-0023469-B1 | AFTER-TREATMENT WITH LIQUID AMMONIA OF CELLULOSIC FIBRE MATERIALS WHICH HAVE BEEN FINISHED WITH FIRE-RETARDANTS | CIBA-GEIGY AG (CH) | 1983-07-20 | — | — | EP | claimed |
| EP-0023469-A1 | After-treatment with liquid ammonia of cellulosic fibre materials which have been finished with fire-retardants | CIBA-GEIGY AG (CH) | 1981-02-04 | — | — | EP | claimed |
| US-7138530-B2 | Thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2006-11-21 | — | — | US | disclosed |
| US-7109354-B2 | Thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2006-09-19 | — | — | US | disclosed |
| EP-1549632-A4 | NOVEL THIOPHENE AMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATING COMPLEMENT-MEDIATED DISEASES AND CONDITIONS | DIMENSIONAL PHARM INC (US) | 2005-11-09 | — | — | EP | disclosed |
| US-20050234081-A1 | Novel thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions | SUBASINGHE NALIN | 2005-10-20 | — | — | US | disclosed |
| EP-1549632-A1 | NOVEL THIOPHENE AMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATING COMPLEMENT-MEDIATED DISEASES AND CONDITIONS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2005-07-06 | — | — | EP | disclosed |
| US-20040009995-A1 | Novel thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2004-01-15 | — | — | US | disclosed |
| WO-2003099805-A1 | NOVEL THIOPHENE AMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATING COMPLEMENT-MEDIATED DISEASES AND CONDITIONS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2003-12-04 | — | — | WO | disclosed |
| EP-0256191-B1 | FIRE RETARDANT FOR WOODY MATERIALS | DAINIPPON INK AND CHEMICALS, INC. (JP) | 1991-12-11 | — | — | EP | disclosed |
| US-4985307-A | 3-(DIALKYLPHOSPHONE)PROPIONAMIDE, AMINO RESIN, MICROENCAPSULATED AMMONIUM POLYPHOSPHATE | DAINIPPON INK AND CHEMICALS, INC. (JP) | 1991-01-15 | — | — | US | disclosed |
| US-4839099-A | 3-DIALKYLPHOSPHONOPROPIONAMIDES; WEATHERPROOFING | DAINIPPON INK AND CHEMICALS, INC. (JP) | 1989-06-13 | — | — | US | disclosed |
| EP-0256191-A1 | Fire retardant for woody materials | DAINIPPON INK AND CHEMICALS, INC. (JP) | 1988-02-24 | — | — | EP | disclosed |
| US-4585703-A | MELAMINE RESIN AND PHOSPHONATE FIREPROOFING AGENT | DAINIPPON INK & CHEMICALS, INC. (JP) | 1986-04-29 | — | — | US | disclosed |
| US-4451262-A | After-treatment of finished, cellulose-containing fibrous materials with liquid ammonia | CIBA-GEIGY CORPORATION (US) | 1984-05-29 | — | — | US | disclosed |
| EP-0023469-B1 | AFTER-TREATMENT WITH LIQUID AMMONIA OF CELLULOSIC FIBRE MATERIALS WHICH HAVE BEEN FINISHED WITH FIRE-RETARDANTS | CIBA-GEIGY AG (CH) | 1983-07-20 | — | — | EP | disclosed |
| EP-0023469-A1 | After-treatment with liquid ammonia of cellulosic fibre materials which have been finished with fire-retardants | CIBA-GEIGY AG (CH) | 1981-02-04 | — | — | EP | disclosed |
| US-3998789-A | FLAME RESISTANT THERMOSETTING RESIN COMPOSITION AND METHOD FOR PREPARING SAME | SUMITOMO BAKELITE COMPANY, LIMITED (JA) | 1976-12-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234081-A1 | Novel thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions | C5, C9, C1R | PPARD 1162/4885TSHR 110/4885TP53 916/4885 |
| US-20040009995-A1 | Novel thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions | C5, C9, C1R | PPARD 2535/4885TSHR 247/4885TP53 1849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.