Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 18/20 | 0.71 |
| ▸ | PRKCA | P17252 | 5/20 | 0.67 |
| ▸ | CCNK | O75909 | 1/20 | 0.51 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.50 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5839245 | 0.90 | CDK1 (0.81) | CDK1PRKCACCNKCDK12CDK5 | |
| SCHEMBL5840267 | 0.90 | CDK1 (0.82) | CDK1PRKCA | |
| SCHEMBL5839387 | 0.84 | CDK1 (0.80) | CDK1PRKCANPC1CDK5CDK5R1 | |
| SCHEMBL5839924 | 0.83 | CDK1 (1.00) | CDK1PRKCANPC1CDK5CDK5R1 | |
| SCHEMBL5840725 | 0.83 | CCNA2 (0.54) | CDK1PRKCANPC1CDK5CDK5R1 | |
| SCHEMBL5840729 | 0.83 | CCNA2 (0.54) | CDK1PRKCANPC1CDK5CDK5R1 | |
| SCHEMBL5840596 | 0.82 | CDK1 (0.70) | CDK1PRKCACCNKCDK12NPC1 | |
| SCHEMBL5839632 | 0.82 | CDK1 (0.71) | CDK1PRKCACCNKCDK12CDK5 | |
| SCHEMBL5840230 | 0.82 | CDK1 (0.82) | CDK1PRKCACCNKCDK12 | |
| SCHEMBL5840226 | 0.82 | CDK1 (1.00) | CDK1PRKCANPC1CDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7091346-B1 | Purine derivatives and processes for their preparation | NOVARTIS AG (CH) | 2006-08-15 | — | — | US | disclosed |
| EP-0874846-B1 | PURINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | NOVARTIS AG (CH) | 2003-04-02 | — | — | EP | disclosed |
| CN-1066147-C | Purine derivatives and process for preparing same | 诺瓦提斯公司 | 2001-05-23 | — | — | CN | disclosed |
| CN-1202896-A | Purine derivatives and processes for their preparation | 诺瓦提斯公司 | 1998-12-23 | — | — | CN | disclosed |
| EP-0874846-A1 | PURINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | Novartis AG (CH) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997016452-A1 | PURINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | NOVARTIS AG (CH) | 1997-05-09 | — | — | WO | disclosed |