Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 17/20 | 0.70 |
| ▸ | PRKCA | P17252 | 5/20 | 0.58 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.57 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.57 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.52 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | MERTK | Q12866 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | CCNK | O75909 | 1/20 | 0.49 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5839982 | 0.91 | CDK1 (0.71) | CDK1PRKCACDK5CDK5R1CCNB1 | |
| SCHEMBL5839952 | 0.85 | CDK5 (0.56) | CDK1PRKCACDK5CDK5R1CCNB1 | |
| SCHEMBL5839936 | 0.85 | CDK5 (0.56) | CDK1PRKCACDK5CDK5R1CCNB1 | |
| SCHEMBL5839245 | 0.84 | CDK1 (0.81) | CDK1PRKCACDK5CDK5R1CCNK | |
| SCHEMBL5840868 | 0.84 | YTHDC1 (0.52) | CDK1PRKCANPC1 | |
| SCHEMBL5839355 | 0.83 | CDK1 (1.00) | CDK1PRKCACDK5CDK5R1CCNB1 | |
| SCHEMBL5840277 | 0.82 | CDK1 (0.71) | CDK1PRKCACDK5CDK5R1NPC1 | |
| SCHEMBL5839924 | 0.82 | CDK1 (1.00) | CDK1PRKCACDK5CDK5R1NPC1 | |
| SCHEMBL5840457 | 0.81 | CDK1 (0.73) | CDK1PRKCACCNB1 | |
| SCHEMBL5840462 | 0.81 | CDK1 (0.73) | CDK1PRKCACCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7091346-B1 | Purine derivatives and processes for their preparation | NOVARTIS AG (CH) | 2006-08-15 | — | — | US | disclosed |
| EP-0874846-B1 | PURINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | NOVARTIS AG (CH) | 2003-04-02 | — | — | EP | disclosed |
| CN-1066147-C | Purine derivatives and process for preparing same | 诺瓦提斯公司 | 2001-05-23 | — | — | CN | disclosed |
| CN-1202896-A | Purine derivatives and processes for their preparation | 诺瓦提斯公司 | 1998-12-23 | — | — | CN | disclosed |
| EP-0874846-A1 | PURINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | Novartis AG (CH) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997016452-A1 | PURINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | NOVARTIS AG (CH) | 1997-05-09 | — | — | WO | disclosed |