Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 3/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.50 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.50 |
| ▸ | CDK2 | P24941 | 2/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
| ▸ | PI4KA | P42356 | 1/20 | 0.44 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.44 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.44 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.44 |
| ▸ | YTHDC1 | Q96MU7 | 9/20 | 0.41 |
| ▸ | PDE8A | O60658 | 2/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3440998 | 0.81 | CDK1 (0.71) | CDK1CCNB1CCNE1CDK2ADORA2A | |
| SCHEMBL29444616 | 0.80 | CDK1 (0.51) | CDK1CCNB1CCNE1CDK2ADORA2A | |
| SCHEMBL183244 | 0.80 | CDK1 (0.51) | CDK1CCNB1CCNE1CDK2ADORA2A | |
| SCHEMBL17364311 | 0.75 | CDK1 (0.46) | CDK1CCNB1CCNE1CDK2ADORA2A | |
| SCHEMBL5838977 | 0.75 | ADORA2A (0.44) | CDK1CCNB1CCNE1CDK2ADORA2A | |
| SCHEMBL5840628 | 0.74 | CDK1 (0.45) | CDK1CCNB1CCNE1CDK2ADORA2A | |
| SCHEMBL5840104 | 0.74 | CDK1 (0.57) | CDK1CCNB1CCNE1CDK2ADORA2A | |
| SCHEMBL25280903 | 0.71 | TLR7 (0.51) | CDK1CCNB1CCNE1CDK2YTHDC1 | |
| SCHEMBL25232611 | 0.71 | YTHDC1 (0.51) | CDK1CCNB1CCNE1CDK2ADORA2A | |
| SCHEMBL17929772 | 0.70 | YTHDC1 (0.63) | CDK1ADORA2AADORA1YTHDC1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7091346-B1 | Purine derivatives and processes for their preparation | NOVARTIS AG (CH) | 2006-08-15 | — | — | US | disclosed |
| EP-0874846-B1 | PURINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | NOVARTIS AG (CH) | 2003-04-02 | — | — | EP | disclosed |
| CN-1066147-C | Purine derivatives and process for preparing same | 诺瓦提斯公司 | 2001-05-23 | — | — | CN | disclosed |
| CN-1202896-A | Purine derivatives and processes for their preparation | 诺瓦提斯公司 | 1998-12-23 | — | — | CN | disclosed |
| EP-0874846-A1 | PURINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | Novartis AG (CH) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997016452-A1 | PURINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | NOVARTIS AG (CH) | 1997-05-09 | — | — | WO | disclosed |