Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 8/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.42 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12522273 | 0.82 | TSHR (0.53) | TSHRTDP1L3MBTL1MAPK1CYP3A4 | |
| SCHEMBL953081 | 0.82 | PTGDR2 (0.55) | TSHRTDP1L3MBTL1MAPK1CYP3A4 | |
| SCHEMBL8619521 | 0.81 | ESR1 (0.52) | TSHRTDP1L3MBTL1MAPK1CYP3A4 | |
| SCHEMBL5841655 | 0.80 | CFTR (0.61) | TDP1MAPK1ALDH1A1HSD17B10LMNA | |
| SCHEMBL5841795 | 0.79 | TSHR (0.49) | TSHRTDP1L3MBTL1MAPK1CYP3A4 | |
| SCHEMBL5841261 | 0.79 | TSHR (0.49) | TSHRTDP1L3MBTL1MAPK1CYP3A4 | |
| SCHEMBL28836075 | 0.77 | TSHR (0.55) | TSHRTDP1L3MBTL1MAPK1CYP3A4 | |
| SCHEMBL8615442 | 0.77 | TSHR (0.52) | TSHRTDP1L3MBTL1MAPK1CYP3A4 | |
| SCHEMBL6788941 | 0.77 | ESR1 (0.66) | TSHRTDP1L3MBTL1MAPK1CYP3A4 | |
| SCHEMBL5841692 | 0.77 | HPD (0.54) | TSHRTDP1L3MBTL1MAPK1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7094919-B2 | Preparation of substituted aromatic carboxylic acid esters | EASTMAN CHEMICAL COMPANY (US) | 2006-08-22 | — | — | US | disclosed |
| EP-1169295-B1 | PREPARATION OF SUBSTITUTED AROMATIC CARBOXYLIC ACID ESTERS | EASTMAN CHEM CO (US) | 2004-07-28 | — | — | EP | disclosed |
| US-20020040159-A1 | Preparation of substituted aromatic carboxylic acid esters | EASTMAN CHEMICAL COMPANY | 2002-04-04 | — | — | US | disclosed |
| EP-1169295-A1 | PREPARATION OF SUBSTITUTED AROMATIC CARBOXYLIC ACID ESTERS | EASTMAN CHEMICAL COMPANY (US) | 2002-01-09 | — | — | EP | disclosed |
| US-6337418-B1 | PALLADIUM COMPLEX-CATALYZED CARBOXYLATION OF NITRO NITRO-SUBSTITUTED ARYL HALIDE, IN ABSENCE OF WATER AND OXYGEN, WITH CARBON MONOXIDE, AN ALCOHOL, PROTON ACCEPTOR; OPTIONAL SULFIDING WITH THIOLATE ANION | EASTMAN CHEMICAL CO. | 2002-01-08 | — | — | US | disclosed |
| WO-2000061538-A1 | PREPARATION OF SUBSTITUTED AROMATIC CARBOXYLIC ACID ESTERS | EASTMAN CHEMICAL COMPANY (US) | 2000-10-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020040159-A1 | Preparation of substituted aromatic carboxylic acid esters | TH, DDC, PAH | TSHR 1852/4885TDP1 1898/4885L3MBTL1 4230/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.