Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | CRHBP | P24387 | 3/20 | 0.54 |
| ▸ | CRHR2 | Q13324 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | ATM | Q13315 | 2/20 | 0.54 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27599102 | 0.87 | ALDH1A1 (0.49) | ALDH1A1KMT2ACRHBPCRHR2L3MBTL1 | |
| SCHEMBL5842814 | 0.80 | ALDH1A1 (0.46) | ALDH1A1KMT2AL3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL27543880 | 0.76 | ALDH1A1 (0.48) | ALDH1A1CRHBPCRHR2L3MBTL1ATM | |
| SCHEMBL8996600 | 0.76 | CRHBP (0.49) | CRHBPCRHR2L3MBTL1MAPTGAA | |
| SCHEMBL31147822 | 0.75 | TSHR (0.46) | ALDH1A1KMT2AMEN1SMN1; SMN2MAPT | |
| SCHEMBL5841770 | 0.75 | ALDH1A1 (0.65) | ALDH1A1KMT2ACRHBPCRHR2L3MBTL1 | |
| SCHEMBL1527805 | 0.74 | AKR1C3 (0.50) | ALDH1A1KMT2AL3MBTL1MEN1MAPT | |
| SCHEMBL8009839 | 0.72 | ANPEP (0.50) | ALDH1A1KMT2AL3MBTL1MEN1SMN1; SMN2 | |
| SCHEMBL6136487 | 0.72 | ALDH1A1 (0.50) | ALDH1A1KMT2ACRHBPCRHR2L3MBTL1 | |
| SCHEMBL1039452 | 0.72 | ALDH1A1 (1.00) | ALDH1A1KMT2ACRHBPCRHR2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050192292-A1 | Pyrrolidone carboxamides | ACTELION PHARMACEUTICALS AG (CH) | 2005-09-01 | — | — | US | claimed |
| US-7067549-B2 | Pyrrolidone carboxamides | ACTELION PHARMACEUTICALS AG (CH) | 2006-06-27 | — | — | US | disclosed |
| US-20050192292-A1 | Pyrrolidone carboxamides | ACTELION PHARMACEUTICALS AG (CH) | 2005-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050192292-A1 | Pyrrolidone carboxamides | NPY1R, NPY5R, NPY2R | ALDH1A1 3034/4885KMT2A 3347/4885CRHBP 312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.