Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 4/20 | 0.39 |
| ▸ | GRM3 | Q14832 | 4/20 | 0.39 |
| ▸ | GRM8 | O00222 | 1/20 | 0.39 |
| ▸ | GRM6 | O15303 | 1/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.35 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29484698 | 1.00 | GRM2 (0.39) | GRM2GRM3GRM8GRM6SLC1A2 | |
| SCHEMBL6527774 | 0.91 | GRM2 (0.35) | GRM2GRM3GRM8GRM6CASP1 | |
| SCHEMBL5841128 | 0.91 | GRM2 (0.35) | GRM2GRM3GRM8GRM6CASP1 | |
| SCHEMBL5840380 | 0.91 | GRM2 (0.35) | GRM2GRM3GRM8GRM6CASP1 | |
| SCHEMBL6526776 | 0.91 | GRM2 (0.35) | GRM2GRM3GRM8GRM6CASP1 | |
| SCHEMBL5847018 | 0.81 | ALDH1A1 (0.38) | CASP1KCNA3 | |
| SCHEMBL5842175 | 0.81 | ALDH1A1 (0.38) | CASP1KCNA3 | |
| SCHEMBL5842801 | 0.80 | GRM2 (0.36) | GRM2GRM3 | |
| SCHEMBL5841180 | 0.80 | GRM2 (0.36) | GRM2GRM3 | |
| SCHEMBL5841443 | 0.79 | GRM2 (0.37) | GRM2GRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7038077-B2 | Prodrugs of excitatory amino acids | ELI LILLY AND COMPANY (US) | 2006-05-02 | — | — | US | disclosed |
| US-20050009912-A1 | Prodrugs of excitatory amino acids | ELI LILLY AND COMPANY | 2005-01-13 | — | — | US | disclosed |
| US-20040248963-A1 | Prodrugs of excitatory amino acids | ELI LILLY AND COMPANY | 2004-12-09 | — | — | US | disclosed |
| US-20040176459-A1 | Prodrugs of excitatory amino acids | ELI LILLY AND COMPANY | 2004-09-09 | — | — | US | disclosed |
| US-20040138304-A1 | Prodrugs of excitatory amino acids | ELI LILLY AND COMPANY | 2004-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040176459-A1 | Prodrugs of excitatory amino acids | SLC1A2, SLC1A1, SLC1A3 | GRM2 22/4885GRM3 25/4885GRM8 44/4885 |
| US-20050009912-A1 | Prodrugs of excitatory amino acids | SLC1A2, SLC1A3, SLC1A1 | GRM2 19/4885GRM3 15/4885GRM8 46/4885 |
| US-20040138304-A1 | Prodrugs of excitatory amino acids | SLC1A2, SLC1A1, SLC1A3 | GRM2 22/4885GRM3 25/4885GRM8 44/4885 |
| US-20040248963-A1 | Prodrugs of excitatory amino acids | SLC1A2, SLC1A1, SLC1A3 | GRM2 20/4885GRM3 21/4885GRM8 52/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.