Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.74 |
| ▸ | HPGD | P15428 | 1/20 | 0.74 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.74 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.74 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.74 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA4 | P22748 | 1/20 | 0.52 |
| ▸ | CA6 | P23280 | 1/20 | 0.52 |
| ▸ | CA7 | P43166 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5843350 | 0.87 | MAPT (0.72) | MAPTALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL5842703 | 0.84 | MAPT (0.57) | MAPTALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL6625375 | 0.83 | MAPT (0.52) | MAPTALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL5843355 | 0.80 | SMN1; SMN2 (0.69) | MAPTALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL5842320 | 0.80 | SMN1; SMN2 (0.69) | MAPTALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL5842314 | 0.78 | SMN1; SMN2 (0.66) | MAPTALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL5841897 | 0.76 | ALDH1A1 (0.58) | MAPTALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL5844742 | 0.76 | ALDH1A1 (0.67) | MAPTALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL5844411 | 0.76 | ALDH1A1 (0.72) | MAPTALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL5842375 | 0.76 | TSHR (0.64) | MAPTHPGDKMT2APOLBCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7067549-B2 | Pyrrolidone carboxamides | ACTELION PHARMACEUTICALS AG (CH) | 2006-06-27 | — | — | US | disclosed |
| US-20050192292-A1 | Pyrrolidone carboxamides | ACTELION PHARMACEUTICALS AG (CH) | 2005-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050192292-A1 | Pyrrolidone carboxamides | NPY1R, NPY5R, NPY2R | MAPT 4395/4885ALDH1A1 3034/4885SMN1; SMN2 3678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.