Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6609944 | 0.88 | MAPT (0.49) | MAPTALDH1A1KDM4ENPSR1MCL1 | |
| SCHEMBL5842470 | 0.83 | MAPT (0.74) | MAPTALDH1A1KDM4ENPSR1MCL1 | |
| SCHEMBL6610605 | 0.78 | ACHE (0.49) | MAPTALDH1A1KDM4ENPSR1MCL1 | |
| SCHEMBL6614799 | 0.77 | MAPT (0.50) | MAPTALDH1A1KDM4ENPSR1MCL1 | |
| SCHEMBL6609399 | 0.75 | ALDH1A1 (0.41) | MAPTALDH1A1KDM4ENPSR1MCL1 | |
| SCHEMBL6613763 | 0.75 | MAPT (0.52) | MAPTALDH1A1NPSR1TP53LMNA | |
| SCHEMBL6610317 | 0.75 | HPGD (0.49) | MAPTHPGDSMN1; SMN2TDP1NPC1 | |
| SCHEMBL6609781 | 0.74 | ALDH1A1 (0.46) | MAPTALDH1A1KDM4ENPSR1MCL1 | |
| SCHEMBL6611922 | 0.73 | ALDH1A1 (0.48) | MAPTALDH1A1KDM4ENPSR1MCL1 | |
| SCHEMBL6614279 | 0.73 | ALOX15 (0.51) | MAPTALDH1A1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463724-A1 | PYRROLIDONE CARBOXAMIDES | Actelion Pharmaceuticals Ltd. (CH) | 2004-10-06 | — | — | EP | disclosed |
| WO-2003059905-A1 | PYRROLIDONE CARBOXAMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2003-07-24 | — | — | WO | disclosed |