Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 18/20 | 0.77 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.77 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.69 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | TSHR | P16473 | 2/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5843412 | 0.87 | OPRK1 (1.00) | OPRK1CYP2D6OPRD1OPRM1CYP3A4 | |
| SCHEMBL5843415 | 0.87 | OPRK1 (1.00) | OPRK1CYP2D6OPRD1OPRM1CYP3A4 | |
| SCHEMBL5842937 | 0.86 | OPRK1 (0.75) | OPRK1CYP2D6OPRD1OPRM1CYP3A4 | |
| Hydrochloric Acid SCHEMBL5844901 | 0.81 | OPRK1 (0.98) | OPRK1CYP2D6OPRD1OPRM1CYP3A4 | |
| Hydrochloric Acid SCHEMBL5844895 | 0.81 | OPRK1 (0.98) | OPRK1CYP2D6OPRD1OPRM1CYP3A4 | |
| SCHEMBL8061918 | 0.80 | OPRK1 (1.00) | OPRK1CYP2D6OPRD1OPRM1CYP3A4 | |
| SCHEMBL17570381 | 0.80 | OPRK1 (1.00) | OPRK1CYP2D6OPRD1OPRM1CYP3A4 | |
| SCHEMBL8061920 | 0.80 | OPRK1 (1.00) | OPRK1CYP2D6OPRD1OPRM1CYP3A4 | |
| Hydrochloric Acid SCHEMBL5844984 | 0.80 | OPRK1 (0.98) | OPRK1CYP2D6OPRD1OPRM1CYP3A4 | |
| Hydrochloric Acid SCHEMBL5844981 | 0.80 | OPRK1 (0.98) | OPRK1CYP2D6OPRD1OPRM1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6992193-B2 | Sulfonylamino phenylacetamide derivatives and methods of their use | ADOLOR CORPORATION (US) | 2006-01-31 | — | — | US | disclosed |
| US-20040254156-A1 | Sulfonylamino phenylacetamide derivatives and methods of their use | CALIXA THERAPEUTICS, INC. | 2004-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040254156-A1 | Sulfonylamino phenylacetamide derivatives and methods of their use | CYP2E1, CYP2D6, CYP3A43 | OPRK1 14/4885CYP2D6 2/4885OPRD1 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.