Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RXFP3 | Q9NSD7 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5841936 | 0.93 | ALDH1A1 (0.49) | ALDH1A1LMNAL3MBTL1HTTNPC1 | |
| SCHEMBL5842770 | 0.84 | ALDH1A1 (0.59) | ALDH1A1LMNAL3MBTL1HTTNPC1 | |
| SCHEMBL5843190 | 0.83 | RXFP3 (0.50) | ALDH1A1LMNAL3MBTL1HTTMAPT | |
| SCHEMBL5843914 | 0.82 | ALDH1A1 (0.72) | ALDH1A1LMNAL3MBTL1HTTNPC1 | |
| SCHEMBL5843797 | 0.81 | NPC1 (0.48) | ALDH1A1LMNAL3MBTL1NPC1GAA | |
| SCHEMBL5843794 | 0.81 | LMNA (0.52) | ALDH1A1LMNAL3MBTL1NPC1GAA | |
| SCHEMBL5841677 | 0.81 | ALDH1A1 (0.49) | ALDH1A1LMNAL3MBTL1HTTNPC1 | |
| SCHEMBL27599365 | 0.81 | MAPT (0.67) | ALDH1A1LMNAL3MBTL1HTTMAPT | |
| SCHEMBL5843041 | 0.80 | ALDH1A1 (0.54) | ALDH1A1LMNAL3MBTL1HTTNPC1 | |
| SCHEMBL6624165 | 0.79 | ALDH1A1 (0.40) | ALDH1A1LMNAL3MBTL1HTTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7067549-B2 | Pyrrolidone carboxamides | ACTELION PHARMACEUTICALS AG (CH) | 2006-06-27 | — | — | US | disclosed |
| US-20050192292-A1 | Pyrrolidone carboxamides | ACTELION PHARMACEUTICALS AG (CH) | 2005-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050192292-A1 | Pyrrolidone carboxamides | NPY1R, NPY5R, NPY2R | ALDH1A1 3034/4885LMNA 3430/4885L3MBTL1 3047/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.